Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/10517
Full metadata record
DC FieldValueLanguage
dc.contributor.authorMussa, Bashair Men
dc.contributor.authorVerberne, Anthony J Men
dc.date.accessioned2015-05-15T23:59:10Z
dc.date.available2015-05-15T23:59:10Z
dc.date.issued2007-12-27en
dc.identifier.citationNeuroscience Letters 2007; 433(1): 71-6en
dc.identifier.govdoc18241988en
dc.identifier.otherPUBMEDen
dc.identifier.urihttp://ahro.austin.org.au/austinjspui/handle/1/10517en
dc.description.abstractPancreatic secretion is regulated by the dorsal vagal nucleus (DVN) which is modulated by several neurotransmitters and diverse synaptic inputs. The inhibitory neurotransmitter GABA is a major modulator of the vagal output to the gastrointestinal tract. The present study investigated the effects of GABA(A) receptor blockade in the DVN, using bicuculline methiodide (BIM, GABA(A) receptor antagonist, 100 pmol/25 nl), on pancreatic exocrine secretion (PES). Male Sprague-Dawley rats anaesthetised with isoflurane were used in all experiments. PES was collected from the common bile-pancreatic duct and was used to determine the pancreatic protein output (PPO). PES and PPO were measured prior to, and after, microinjection of BIM into the DVN. Bilateral microinjection of BIM into the DVN significantly increased PES and PPO from 23.4+/-3.2 microl/h to 66.1+/-17.5 microl/h and 19.3+/-1.7 microg/h to 35.7+/-3.0 microg/h (P<0.05), respectively. Atropine methonitrate (100 microg/(kg min), i.v.) blocked the excitatory effect of BIM microinjection on PES and PPO. These results suggest that activation of DVN neurons stimulates pancreatic secretion via a cholinergic muscarinic mechanism.en
dc.language.isoenen
dc.subject.otherAcetylcholine.metabolismen
dc.subject.otherAnimalsen
dc.subject.otherCholinergic Fibers.drug effects.metabolismen
dc.subject.otherElectric Stimulationen
dc.subject.otherEnzymes.secretionen
dc.subject.otherGABA Antagonists.pharmacologyen
dc.subject.otherGABA-A Receptor Antagonistsen
dc.subject.otherMaleen
dc.subject.otherMedulla Oblongata.drug effects.physiologyen
dc.subject.otherMicroelectrodesen
dc.subject.otherMicroinjectionsen
dc.subject.otherMuscarinic Agonists.pharmacologyen
dc.subject.otherMuscarinic Antagonists.pharmacologyen
dc.subject.otherNeurons, Efferent.drug effects.physiologyen
dc.subject.otherPancreas, Exocrine.innervation.secretionen
dc.subject.otherRatsen
dc.subject.otherRats, Sprague-Dawleyen
dc.subject.otherReceptors, GABA-A.metabolismen
dc.subject.otherReceptors, Muscarinic.drug effects.metabolismen
dc.subject.otherSynaptic Transmission.drug effects.physiologyen
dc.subject.otherVagus Nerve.drug effects.physiologyen
dc.subject.othergamma-Aminobutyric Acid.metabolismen
dc.titleActivation of the dorsal vagal nucleus increases pancreatic exocrine secretion in the rat.en
dc.typeJournal Articleen
dc.identifier.journaltitleNeuroscience lettersen
dc.identifier.affiliationUniversity of Melbourne, Department of Medicine, Clinical Pharmacology and Therapeutics Unit, Austin Health, Heidelberg 3084, Victoria, Australiaen
dc.identifier.doi10.1016/j.neulet.2007.12.048en
dc.description.pages71-6en
dc.relation.urlhttps://pubmed.ncbi.nlm.nih.gov/18241988en
dc.type.austinJournal Articleen
item.grantfulltextnone-
item.languageiso639-1en-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.openairetypeJournal Article-
item.fulltextNo Fulltext-
item.cerifentitytypePublications-
crisitem.author.deptClinical Pharmacology and Therapeutics-
crisitem.author.deptMedicine (University of Melbourne)-
Appears in Collections:Journal articles
Show simple item record

Google ScholarTM

Check


Items in AHRO are protected by copyright, with all rights reserved, unless otherwise indicated.