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dc.contributor.authorMulvany, Nicholas Jen
dc.contributor.authorAllen, David Gen
dc.identifier.citationInternational Journal of Gynecological Pathology : Official Journal of the International Society of Gynecological Pathologists; 27(1): 49-57en
dc.description.abstractWe present the surgical and pathological findings and follow-up of 5 women diagnosed with combined endometrioid and high-grade neuroendocrine carcinoma of large cell type (LCNEC) arising in the endometrium. The mean age of the women was 75 years (range, 50-88 years). Of the 5 tumors, 4 formed polypoid endometrial masses associated with extensive lymphovascular involvement of the myometrium by neoplastic cells. A single endometrial tumor was formed by LCNEC alone, and 4 tumors were composite with varying proportions formed by endometrioid (4/5) and small cell neuroendocrine carcinoma (1/5). In all 5 LCNEC tumor components, an insular growth pattern was noted, whereas a diffuse (solid) pattern was found in 4 tumors, a trabecular in 2, and rosettes/pseudorosettes in another 2. In all 5 tumors, the LCNEC tumor components were labeled with neuron-specific enolase (NSE). Four tumors were reactive for chromogranin A, CAM 5.2, and p53. Three tumors were labeled for AE1/AE3, CD56 (NCAM), p16, and cytokeratin 7. Synaptophysin was reactive in 2 tumors, and CD117 was found in only a single tumor. Of the 3 endometrioid tumor components examined, all were reactive for NSE. Two tumors were reactive for p16 and p53, 1 for CD56, but none for synaptophysin orchromogranin A. We conclude that LCNEC of the endometrium is a distinct clinicopathological entity with a poor prognosis irrespective of stage. The gross and histomorphological features are often suggestive, but confirmation requires immunoperoxidases, including NSE, synaptophysin, chromogranin A, p16, and p53. Combined endometrioid and high-grade LCNEC possess more characteristics of a type II than a type I endometrial carcinoma.en
dc.subject.otherAged, 80 and overen
dc.subject.otherCarcinoma, Endometrioid.metabolism.pathologyen
dc.subject.otherCarcinoma, Large Cell.metabolism.pathologyen
dc.subject.otherCarcinoma, Neuroendocrine.metabolism.pathologyen
dc.subject.otherEndometrial Neoplasms.metabolism.pathologyen
dc.subject.otherMiddle Ageden
dc.subject.otherTumor Markers, Biological.analysisen
dc.titleCombined large cell neuroendocrine and endometrioid carcinoma of the endometrium.en
dc.typeJournal Articleen
dc.identifier.journaltitleInternational journal of gynecological pathology : official journal of the International Society of Gynecological Pathologistsen
dc.identifier.affiliationDepartment of Anatomical Pathology, Austin Hospital, Heidelberg, Victoria, Australiaen
dc.type.austinJournal Articleen
item.fulltextNo Fulltext-
item.openairetypeJournal Article-
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