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https://ahro.austin.org.au/austinjspui/handle/1/10490
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DC Field | Value | Language |
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dc.contributor.author | Mulvany, Nicholas J | en |
dc.contributor.author | Allen, David G | en |
dc.date.accessioned | 2015-05-15T23:57:08Z | |
dc.date.available | 2015-05-15T23:57:08Z | |
dc.date.issued | 2008-01-01 | en |
dc.identifier.citation | International Journal of Gynecological Pathology : Official Journal of the International Society of Gynecological Pathologists; 27(1): 49-57 | en |
dc.identifier.govdoc | 18156975 | en |
dc.identifier.other | PUBMED | en |
dc.identifier.uri | https://ahro.austin.org.au/austinjspui/handle/1/10490 | en |
dc.description.abstract | We present the surgical and pathological findings and follow-up of 5 women diagnosed with combined endometrioid and high-grade neuroendocrine carcinoma of large cell type (LCNEC) arising in the endometrium. The mean age of the women was 75 years (range, 50-88 years). Of the 5 tumors, 4 formed polypoid endometrial masses associated with extensive lymphovascular involvement of the myometrium by neoplastic cells. A single endometrial tumor was formed by LCNEC alone, and 4 tumors were composite with varying proportions formed by endometrioid (4/5) and small cell neuroendocrine carcinoma (1/5). In all 5 LCNEC tumor components, an insular growth pattern was noted, whereas a diffuse (solid) pattern was found in 4 tumors, a trabecular in 2, and rosettes/pseudorosettes in another 2. In all 5 tumors, the LCNEC tumor components were labeled with neuron-specific enolase (NSE). Four tumors were reactive for chromogranin A, CAM 5.2, and p53. Three tumors were labeled for AE1/AE3, CD56 (NCAM), p16, and cytokeratin 7. Synaptophysin was reactive in 2 tumors, and CD117 was found in only a single tumor. Of the 3 endometrioid tumor components examined, all were reactive for NSE. Two tumors were reactive for p16 and p53, 1 for CD56, but none for synaptophysin orchromogranin A. We conclude that LCNEC of the endometrium is a distinct clinicopathological entity with a poor prognosis irrespective of stage. The gross and histomorphological features are often suggestive, but confirmation requires immunoperoxidases, including NSE, synaptophysin, chromogranin A, p16, and p53. Combined endometrioid and high-grade LCNEC possess more characteristics of a type II than a type I endometrial carcinoma. | en |
dc.language.iso | en | en |
dc.subject.other | Aged | en |
dc.subject.other | Aged, 80 and over | en |
dc.subject.other | Carcinoma, Endometrioid.metabolism.pathology | en |
dc.subject.other | Carcinoma, Large Cell.metabolism.pathology | en |
dc.subject.other | Carcinoma, Neuroendocrine.metabolism.pathology | en |
dc.subject.other | Endometrial Neoplasms.metabolism.pathology | en |
dc.subject.other | Female | en |
dc.subject.other | Humans | en |
dc.subject.other | Immunohistochemistry | en |
dc.subject.other | Middle Aged | en |
dc.subject.other | Tumor Markers, Biological.analysis | en |
dc.title | Combined large cell neuroendocrine and endometrioid carcinoma of the endometrium. | en |
dc.type | Journal Article | en |
dc.identifier.journaltitle | International journal of gynecological pathology : official journal of the International Society of Gynecological Pathologists | en |
dc.identifier.affiliation | Department of Anatomical Pathology, Austin Hospital, Heidelberg, Victoria, Australia | en |
dc.identifier.doi | 10.1097/pgp.0b013e31806219c5 | en |
dc.description.pages | 49-57 | en |
dc.relation.url | https://pubmed.ncbi.nlm.nih.gov/18156975 | en |
dc.type.austin | Journal Article | en |
item.openairetype | Journal Article | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.grantfulltext | none | - |
item.fulltext | No Fulltext | - |
item.cerifentitytype | Publications | - |
item.languageiso639-1 | en | - |
Appears in Collections: | Journal articles |
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