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Title: | Combined large cell neuroendocrine and endometrioid carcinoma of the endometrium. | Austin Authors: | Mulvany, Nicholas J;Allen, David G | Affiliation: | Department of Anatomical Pathology, Austin Hospital, Heidelberg, Victoria, Australia | Issue Date: | 1-Jan-2008 | Publication information: | International Journal of Gynecological Pathology : Official Journal of the International Society of Gynecological Pathologists; 27(1): 49-57 | Abstract: | We present the surgical and pathological findings and follow-up of 5 women diagnosed with combined endometrioid and high-grade neuroendocrine carcinoma of large cell type (LCNEC) arising in the endometrium. The mean age of the women was 75 years (range, 50-88 years). Of the 5 tumors, 4 formed polypoid endometrial masses associated with extensive lymphovascular involvement of the myometrium by neoplastic cells. A single endometrial tumor was formed by LCNEC alone, and 4 tumors were composite with varying proportions formed by endometrioid (4/5) and small cell neuroendocrine carcinoma (1/5). In all 5 LCNEC tumor components, an insular growth pattern was noted, whereas a diffuse (solid) pattern was found in 4 tumors, a trabecular in 2, and rosettes/pseudorosettes in another 2. In all 5 tumors, the LCNEC tumor components were labeled with neuron-specific enolase (NSE). Four tumors were reactive for chromogranin A, CAM 5.2, and p53. Three tumors were labeled for AE1/AE3, CD56 (NCAM), p16, and cytokeratin 7. Synaptophysin was reactive in 2 tumors, and CD117 was found in only a single tumor. Of the 3 endometrioid tumor components examined, all were reactive for NSE. Two tumors were reactive for p16 and p53, 1 for CD56, but none for synaptophysin orchromogranin A. We conclude that LCNEC of the endometrium is a distinct clinicopathological entity with a poor prognosis irrespective of stage. The gross and histomorphological features are often suggestive, but confirmation requires immunoperoxidases, including NSE, synaptophysin, chromogranin A, p16, and p53. Combined endometrioid and high-grade LCNEC possess more characteristics of a type II than a type I endometrial carcinoma. | Gov't Doc #: | 18156975 | URI: | http://ahro.austin.org.au/austinjspui/handle/1/10490 | DOI: | 10.1097/pgp.0b013e31806219c5 | Journal: | International journal of gynecological pathology : official journal of the International Society of Gynecological Pathologists | URL: | https://pubmed.ncbi.nlm.nih.gov/18156975 | Type: | Journal Article | Subjects: | Aged Aged, 80 and over Carcinoma, Endometrioid.metabolism.pathology Carcinoma, Large Cell.metabolism.pathology Carcinoma, Neuroendocrine.metabolism.pathology Endometrial Neoplasms.metabolism.pathology Female Humans Immunohistochemistry Middle Aged Tumor Markers, Biological.analysis |
Appears in Collections: | Journal articles |
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