Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/10487
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dc.contributor.authorSong, K Fen
dc.contributor.authorZhuo, J Len
dc.contributor.authorMendelsohn, Frederick AOen
dc.date.accessioned2015-05-15T23:56:54Z
dc.date.available2015-05-15T23:56:54Z
dc.date.issued1991-12-01en
dc.identifier.citationBritish Journal of Pharmacology; 104(4): 771-2en
dc.identifier.govdoc1810594en
dc.identifier.otherPUBMEDen
dc.identifier.urihttp://ahro.austin.org.au/austinjspui/handle/1/10487en
dc.description.abstractThe in vivo access of the nonpeptide angiotensin II (Ang II) antagonist, DuP 753 (10 mg kg-1, i.v.), to Ang II receptors of rat brain was investigated by in vitro autoradiography with [125I]-[Sar1, Ile8] Ang II as a ligand. DuP 753 markedly inhibited the binding to sites which contain exclusively AT1 receptors both outside and within the blood brain barrier, such as the circumventricular organs, paraventricular hypothalamic nucleus, median preoptic nucleus and nucleus of the solitary tract. However, binding to other nuclei containing AT2 receptors was not significantly inhibited. These results demonstrate that DuP 753 and/or its active metabolite readily cross the blood brain barrier in vivo and selectively inhibit binding to AT1 receptors in specific brain nuclei.en
dc.language.isoenen
dc.subject.other1-Sarcosine-8-Isoleucine Angiotensin II.pharmacologyen
dc.subject.otherAngiotensin II.antagonists & inhibitorsen
dc.subject.otherAngiotensin Receptor Antagonistsen
dc.subject.otherAnimalsen
dc.subject.otherAutoradiographyen
dc.subject.otherBiphenyl Compounds.administration & dosage.pharmacologyen
dc.subject.otherBrain Chemistry.drug effectsen
dc.subject.otherImidazoles.administration & dosage.pharmacologyen
dc.subject.otherIodine Radioisotopes.diagnostic useen
dc.subject.otherLosartanen
dc.subject.otherMaleen
dc.subject.otherMedulla Oblongata.drug effects.physiologyen
dc.subject.otherRatsen
dc.subject.otherRats, Inbred Strainsen
dc.subject.otherTetrazoles.administration & dosage.pharmacologyen
dc.titleAccess of peripherally administered DuP 753 to rat brain angiotensin II receptors.en
dc.typeJournal Articleen
dc.identifier.journaltitleBritish journal of pharmacologyen
dc.identifier.affiliationDepartment of Medicine, Austin Hospital, University of Melbourne, Heidelberg, Victoria, Australiaen
dc.description.pages771-2en
dc.relation.urlhttps://pubmed.ncbi.nlm.nih.gov/1810594en
dc.type.austinJournal Articleen
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.fulltextNo Fulltext-
item.cerifentitytypePublications-
item.grantfulltextnone-
item.languageiso639-1en-
item.openairetypeJournal Article-
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