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Title: Ontogeny of neurotensin in the fetal sheep.
Austin Authors: Read, D M;Shulkes, Arthur
Affiliation: Department of Surgery, University of Melbourne, Austin Hospital, Victoria, Australia
Issue Date: 1-Sep-1991
Publication information: Journal of Developmental Physiology; 16(3): 155-62
Abstract: Neurotensin (NT) is a regulatory peptide involved in the control of gastrointestinal function. We have used the chronically cannulated ovine fetus to examine the ontogeny of circulating NT-like immunoreactivity (NTLI) in the fetus and neonatal lamb. In addition the placental transfer and clearance of NT has been determined. NTLI in the ovine fetus circulates at adult concentrations during the third trimester of pregnancy and is of fetal origin. NTLI is present in the fetal ileum, the richest source of NT, at adult concentrations and in the same molecular profile as in the adult. There is a transient increase in circulating NTLI at birth, and a small NT response to feeding in the lamb. While fetal concentrations of plasma NTLI are generally the same as in the adult and originate from the fetus, the fetus clears infused NT(1-13) twice as rapidly as the nonpregnant adult indicating a higher fetal production of NT. Thus it appears that the mechanisms involved in the production and processing of NT are mature some weeks before birth.
Gov't Doc #: 1797922
Type: Journal Article
Subjects: Animals
Animals, Newborn
Embryonic and Fetal Development
Fetal Blood.metabolism
Maternal-Fetal Exchange
Appears in Collections:Journal articles

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