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Title: Hypoxia positron emission tomography imaging with 18f-fluoromisonidazole.
Austin Authors: Lee, Sze Ting ;Scott, Andrew M 
Affiliation: Centre for PET, Austin Health, Heidelberg, Victoria, Australia
Issue Date: 1-Nov-2007
Publication information: Seminars in Nuclear Medicine; 37(6): 451-61
Abstract: The importance of hypoxia in disease pathogenesis and prognosis is gathering increasing clinical significance and having a greater impact on patient management and outcome. Previous efforts to evaluate hypoxia have included the invasive assessment of hypoxia with immunohistologic and histographic oxygen probes. The emergence of new radiotracers has allowed noninvasive assessment of hypoxia, with the most extensively investigated and validated positron emission tomography radiotracer of hypoxia to date being (18)F-fluoromisonodazole ((18)F-FMISO). This review discusses the relevance and biology of hypoxia in cells and organ systems, and reviews the laboratory and clinical applications of (18)F-FMISO in oncology and noncancer disease states.
Gov't Doc #: 17920352
DOI: 10.1053/j.semnuclmed.2007.07.001
Type: Journal Article
Subjects: Animals
Brain Ischemia.metabolism.radionuclide imaging
Brain Neoplasms.metabolism.radionuclide imaging
Carcinoma, Non-Small-Cell Lung.metabolism.radionuclide imaging
Cell Hypoxia
Fluorine Radioisotopes
Glioma.metabolism.radionuclide imaging
Head and Neck Neoplasms.metabolism.radionuclide imaging
Lung Neoplasms.metabolism.radionuclide imaging
Misonidazole.analogs & derivatives.chemical synthesis.diagnostic use.pharmacokinetics
Myocardial Ischemia.metabolism.radionuclide imaging
Neoplasms.metabolism.radionuclide imaging
Positron-Emission Tomography
Radiopharmaceuticals.chemical synthesis.diagnostic use.pharmacokinetics
Stroke.metabolism.radionuclide imaging
Appears in Collections:Journal articles

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