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Title: Is hospital-in-the-home (HITH) treatment of bacterial endocarditis safe and effective?
Austin Authors: McMahon, James H;O'keeffe, Jason M;Grayson, M Lindsay 
Institutional Author: Victorian Hith Outcomes Study Group
Affiliation: Infectious Diseases
Issue Date: 3-Aug-2007
Publication information: Scandinavian Journal of Infectious Diseases 2007; 40(1): 40-3
Abstract: Although serious infections such as bacterial endocarditis (BE) are being increasingly treated with parenteral antibiotics via Hospital-in-the-Home (HITH) programmes in Australia, there are few published data to confirm the safety and efficacy of this treatment modality, especially among patients with BE due to pathogens other than streptococci. In a 12-month prospective, multi-site study we assessed HITH treatment outcomes for all cases of BE. Among the 40 BE cases (29 'definite', 11 'possible'; Duke criteria) caused by a range of pathogens (16 staphylococci spp., 11 streptococci, 4 other, 9 culture-negative), cure was achieved in 37 (93%) cases. BE due to Staphylococcus aureus was significantly associated with an inferior outcome (p =0.046). Adverse events were relatively common (9/40), but most were not severe and were managed with continuation of HITH care. BE can be safely managed via HITH, but particular care in patient selection is necessary, especially for cases due to S. aureus.
DOI: 10.1080/00365540701522942
Journal: Scandinavian Journal of Infectious Diseases
Type: Journal Article
Subjects: Adult
Anti-Bacterial Agents.therapeutic use
Endocarditis, Bacterial.drug therapy
Home Care Services
Middle Aged
Patient Selection
Pilot Projects
Prospective Studies
Appears in Collections:Journal articles

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