Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/10386
Title: Is photosensitive epilepsy less common in males due to variation in X chromosome photopigment genes?
Austin Authors: Taylor, Isabella;Hodgson, Bree;Scheffer, Ingrid E ;Mulley, John C;Berkovic, Samuel F ;Dibbens, Leanne M
Affiliation: Epilepsy Research Centre, The University of Melbourne, Austin Health, Heidelberg Victoria, Australia
Issue Date: 23-May-2007
Publication information: Epilepsia 2007; 48(9): 1807-9
Abstract: Photosensitive epilepsy is less frequent among males than females. Red is the most epileptogenic color. The X-linked red pigment gene contains the polymorphism Ser180Ala; the Ser180 allele increases red sensitivity. We hypothesized that the paucity of males with photosensitive epilepsy is explained by the distribution of this sex-linked allele, and predicted photosensitive males would have a low frequency of this allele. We genotyped 35 males with photosensitive epilepsy and 84 male controls. Allele frequencies did not differ between these groups. The hypothesis was not supported, so alternate reasons for the sex bias in photosensitive epilepsy must be sought.
Gov't Doc #: 17521342
URI: http://ahro.austin.org.au/austinjspui/handle/1/10386
DOI: 10.1111/j.1528-1167.2007.01138.x
URL: https://pubmed.ncbi.nlm.nih.gov/17521342
Type: Journal Article
Subjects: Australia.epidemiology
Chromosomes, Human, X.genetics
Electroencephalography.statistics & numerical data
Epilepsy, Reflex.epidemiology.genetics
Gene Frequency
Genes, X-Linked.genetics
Genetic Predisposition to Disease.genetics
Genetic Variation.genetics
Genotype
Humans
Male
Polymorphism, Genetic.genetics
Retinal Cone Photoreceptor Cells.physiology
Retinal Pigments.genetics
Sex Characteristics
Sex Factors
Appears in Collections:Journal articles

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