Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/10379
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dc.contributor.authorChitravas, Nen
dc.contributor.authorDewey, Helen Men
dc.contributor.authorNicol, M Ben
dc.contributor.authorHarding, D Len
dc.contributor.authorPearce, D Cen
dc.contributor.authorThrift, Amanda Gen
dc.date.accessioned2015-05-15T23:48:44Z
dc.date.available2015-05-15T23:48:44Z
dc.date.issued2007-05-15en
dc.identifier.citationNeurology; 68(20): 1687-93en
dc.identifier.govdoc17502550en
dc.identifier.otherPUBMEDen
dc.identifier.urihttp://ahro.austin.org.au/austinjspui/handle/1/10379en
dc.description.abstractThere is evidence that angiotensin-converting enzyme inhibitors (ACEIs) reduce the risk of stroke. However, it is unclear whether ACEI use before stroke provides a vasoprotective effect resulting in less severe stroke.We ascertained all strokes occurring in a defined population in Melbourne, Australia. Prestroke use of ACEIs and concomitant medications was obtained from medical records. Initial neurologic deficit was dichotomized according to a NIH Stroke Scale (NIHSS) score < 8 (less severe deficit) or > or = 8 (severe deficit). Logistic regression was used to assess the association between prestroke use of ACEIs and stroke severity (measured by severity of neurologic deficits and death at 28 days).Seven hundred sixteen first-ever ischemic stroke patients were included. Previous use of ACEIs was independently associated with a reduced risk of severe neurologic deficits (odds ratio [OR] 0.56; 95% CI 0.35 to 0.91) and death within 28 days (OR 0.46; 95% CI 0.24 to 0.87). Diuretics were associated with an increased risk of severe neurologic deficits (OR 1.81; 95% CI 1.13 to 2.90). Factors associated with a greater NIHSS score were older age, atrial fibrillation, heart failure, and use of diuretics. These factors and claudication were associated with an increased risk of 28-day mortality, whereas use of anticoagulants was associated with a reduced risk of severe neurologic deficits and death.Within this large community-based cohort, prestroke use of angiotensin-converting enzyme inhibitors was associated with a reduced risk of severe stroke.en
dc.language.isoenen
dc.subject.otherAgeden
dc.subject.otherAngiotensin-Converting Enzyme Inhibitors.therapeutic useen
dc.subject.otherAnticoagulants.therapeutic useen
dc.subject.otherAntihypertensive Agents.therapeutic useen
dc.subject.otherBrain Damage, Chronic.epidemiology.etiology.prevention & controlen
dc.subject.otherBrain Ischemia.complications.epidemiology.mortalityen
dc.subject.otherCardiovascular Diseases.drug therapy.epidemiologyen
dc.subject.otherCohort Studiesen
dc.subject.otherComorbidityen
dc.subject.otherConfounding Factors (Epidemiology)en
dc.subject.otherDiuretics.therapeutic useen
dc.subject.otherFemaleen
dc.subject.otherHumansen
dc.subject.otherHydroxymethylglutaryl-CoA Reductase Inhibitors.therapeutic useen
dc.subject.otherMaleen
dc.subject.otherMiddle Ageden
dc.subject.otherOdds Ratioen
dc.subject.otherPlatelet Aggregation Inhibitors.therapeutic useen
dc.subject.otherPrognosisen
dc.subject.otherRisken
dc.subject.otherRisk Factorsen
dc.subject.otherSeverity of Illness Indexen
dc.subject.otherSurvival Analysisen
dc.subject.otherTime Factorsen
dc.subject.otherVictoria.epidemiologyen
dc.titleIs prestroke use of angiotensin-converting enzyme inhibitors associated with better outcome?en
dc.typeJournal Articleen
dc.identifier.journaltitleNeurologyen
dc.identifier.affiliationNational Stroke Research Institute, Austin Health, Heidelberg Heights, Victoria, Australiaen
dc.identifier.doi10.1212/01.wnl.0000261914.18101.60en
dc.description.pages1687-93en
dc.relation.urlhttps://pubmed.ncbi.nlm.nih.gov/17502550en
dc.type.austinJournal Articleen
item.grantfulltextnone-
item.cerifentitytypePublications-
item.fulltextNo Fulltext-
item.openairetypeJournal Article-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.languageiso639-1en-
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