Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/10375
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dc.contributor.authorAllen, A Men
dc.contributor.authorPaxinos, Gen
dc.contributor.authorMcKinley, M Jen
dc.contributor.authorChai, Syn Yen
dc.contributor.authorMendelsohn, Frederick AOen
dc.date.accessioned2015-05-15T23:48:26Z
dc.date.available2015-05-15T23:48:26Z
dc.date.issued1991-10-08en
dc.identifier.citationThe Journal of Comparative Neurology; 312(2): 291-8en
dc.identifier.govdoc1748734en
dc.identifier.otherPUBMEDen
dc.identifier.urihttp://ahro.austin.org.au/austinjspui/handle/1/10375en
dc.description.abstractAngiotensin II (Ang II) binding sites were localized in the thalamus, basal ganglia, midbrain, and pons of the human central nervous system by in vitro autoradiography, employing 125I-[Sar1, Ile8]angiotensin II as the radioligand. High-density binding occurs in the substantia nigra pars compacta, the interpeduncular nucleus and two of the raphe nuclei, the raphe magnus, and median raphe nucleus. Moderate densities occur in the caudate nucleus, putamen, bed nucleus of the stria terminalis, rostral linear nucleus, caudal linear nucleus, dorsal and paramedian raphe nuclei, locus coeruleus, and region of the subcoeruleus, oral dorsal paramedian nucleus, and A5/periolivary region. Low levels occur in the region between the subthalamic nucleus and the zona incerta, the mediodorsal thalamic nucleus, the central gray, the lateral and medial parabrachial nuclei, and the molecular layer of the cerebellum. The high density of Ang II receptor binding in the substantia nigra occurs over pigmented, presumably dopaminergic, neurons. The binding in this site, and in the striatum, is not observed in any of the other species we have studied. It displays similar pharmacological characteristics to the Ang II receptor binding site in other regions of the human brain. Overall we demonstrate a discrete pattern of Ang II receptor binding sites in the human brain, which shows a high correlation with the distribution observed in other mammalian species.en
dc.language.isoenen
dc.subject.other1-Sarcosine-8-Isoleucine Angiotensin II.metabolismen
dc.subject.otherAgeden
dc.subject.otherAngiotensin II.metabolismen
dc.subject.otherAutoradiographyen
dc.subject.otherBasal Ganglia.metabolismen
dc.subject.otherBinding Sitesen
dc.subject.otherCerebellum.metabolismen
dc.subject.otherFemaleen
dc.subject.otherHumansen
dc.subject.otherMaleen
dc.subject.otherMesencephalonen
dc.subject.otherPons.metabolismen
dc.subject.otherProsencephalon.metabolismen
dc.subject.otherReceptors, Angiotensin.metabolismen
dc.subject.otherThalamus.metabolismen
dc.subject.otherTissue Distributionen
dc.titleLocalization and characterization of angiotensin II receptor binding sites in the human basal ganglia, thalamus, midbrain pons, and cerebellum.en
dc.typeJournal Articleen
dc.identifier.journaltitleThe Journal of comparative neurologyen
dc.identifier.affiliationUniversity of Melbourne Department of Medicine, Austin Hospital, Heidelberg, Victoria, Australiaen
dc.identifier.doi10.1002/cne.903120211en
dc.description.pages291-8en
dc.relation.urlhttps://pubmed.ncbi.nlm.nih.gov/1748734en
dc.type.austinJournal Articleen
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.fulltextNo Fulltext-
item.cerifentitytypePublications-
item.grantfulltextnone-
item.languageiso639-1en-
item.openairetypeJournal Article-
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