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Title: Localization and characterization of angiotensin II receptor binding sites in the human basal ganglia, thalamus, midbrain pons, and cerebellum.
Austin Authors: Allen, A M;Paxinos, G;McKinley, M J;Chai, Syn Y;Mendelsohn, Frederick AO
Affiliation: University of Melbourne Department of Medicine, Austin Hospital, Heidelberg, Victoria, Australia
Issue Date: 8-Oct-1991
Publication information: The Journal of Comparative Neurology; 312(2): 291-8
Abstract: Angiotensin II (Ang II) binding sites were localized in the thalamus, basal ganglia, midbrain, and pons of the human central nervous system by in vitro autoradiography, employing 125I-[Sar1, Ile8]angiotensin II as the radioligand. High-density binding occurs in the substantia nigra pars compacta, the interpeduncular nucleus and two of the raphe nuclei, the raphe magnus, and median raphe nucleus. Moderate densities occur in the caudate nucleus, putamen, bed nucleus of the stria terminalis, rostral linear nucleus, caudal linear nucleus, dorsal and paramedian raphe nuclei, locus coeruleus, and region of the subcoeruleus, oral dorsal paramedian nucleus, and A5/periolivary region. Low levels occur in the region between the subthalamic nucleus and the zona incerta, the mediodorsal thalamic nucleus, the central gray, the lateral and medial parabrachial nuclei, and the molecular layer of the cerebellum. The high density of Ang II receptor binding in the substantia nigra occurs over pigmented, presumably dopaminergic, neurons. The binding in this site, and in the striatum, is not observed in any of the other species we have studied. It displays similar pharmacological characteristics to the Ang II receptor binding site in other regions of the human brain. Overall we demonstrate a discrete pattern of Ang II receptor binding sites in the human brain, which shows a high correlation with the distribution observed in other mammalian species.
Gov't Doc #: 1748734
DOI: 10.1002/cne.903120211
Journal: The Journal of comparative neurology
Type: Journal Article
Subjects: 1-Sarcosine-8-Isoleucine Angiotensin II.metabolism
Angiotensin II.metabolism
Basal Ganglia.metabolism
Binding Sites
Receptors, Angiotensin.metabolism
Tissue Distribution
Appears in Collections:Journal articles

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