Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/10310
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dc.contributor.authorWang, Qingjuen
dc.contributor.authorAlén, Markkuen
dc.contributor.authorNicholson, Patricken
dc.contributor.authorSuominen, Harrien
dc.contributor.authorKoistinen, Arvoen
dc.contributor.authorKröger, Heikkien
dc.contributor.authorCheng, Sulinen
dc.date.accessioned2015-05-15T23:43:27Z
dc.date.available2015-05-15T23:43:27Z
dc.date.issued2006-12-21en
dc.identifier.citationBone 2006; 40(5): 1196-202en
dc.identifier.govdoc17258519en
dc.identifier.otherPUBMEDen
dc.identifier.urihttp://ahro.austin.org.au/austinjspui/handle/1/10310en
dc.description.abstractThe mechanical environment is considered to be the most important determinant of bone strength. Local muscle force, in turn, is regarded as the largest source of loading applied to bones. However, the effect of weight-bearing on bone mineral accrual is unclear. Comparing the relationship between muscle force and bone mineral content (BMC) in the upper and lower limbs provides a means of investigating this issue.The study group comprised 258 healthy girls aged 10-13 years old at baseline. BMC, lean body mass (LM) and fat body mass (FM) of total body were assessed by dual-energy X-ray absorptiometry at baseline and 2 years after. The maximal isometric voluntary contraction (MVC) of left elbow flexors and knee extensors was evaluated by a dynamometer. A hierarchical linear statistical model with random effects was used to analyze the relationship between BMC and limb-matched MVC. Fisher's z-transformation was used to compare the correlation coefficients between arms and legs. The ratio of BMC to MVC (BMC/MVC) in upper and lower limbs was compared using Student's t-test.BMC was highly correlated with MVC in arms and legs (r(2)=0.54 and 0.50, respectively), and the correlation coefficients did not differ between upper and lower limbs. On the other hand, BMC/MVC was significantly (30%) higher in leg than in arm.The results indicate that local muscle contraction and weight-bearing exert an additive effect on bone mass accretion in the lower limbs. Exercise regimes combining resistance and impact training should provide larger bone response than either one of them alone in growing children.en
dc.language.isoenen
dc.subject.otherAdolescenten
dc.subject.otherBody Mass Indexen
dc.subject.otherBone Density.physiologyen
dc.subject.otherChilden
dc.subject.otherFemaleen
dc.subject.otherFollow-Up Studiesen
dc.subject.otherHumansen
dc.subject.otherLongitudinal Studiesen
dc.subject.otherMuscle Contractionen
dc.subject.otherMuscles.physiologyen
dc.subject.otherPuberty.physiologyen
dc.subject.otherTime Factorsen
dc.subject.otherWeight-Bearing.physiologyen
dc.titleWeight-bearing, muscle loading and bone mineral accrual in pubertal girls--a 2-year longitudinal study.en
dc.typeJournal Articleen
dc.identifier.journaltitleBoneen
dc.identifier.affiliationEndocrine Center, Austin Health, University of Melbourne, Heidelberg, VIC 3084, Australiaen
dc.identifier.doi10.1016/j.bone.2006.12.054en
dc.description.pages1196-202en
dc.relation.urlhttps://pubmed.ncbi.nlm.nih.gov/17258519en
dc.type.austinJournal Articleen
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.fulltextNo Fulltext-
item.cerifentitytypePublications-
item.grantfulltextnone-
item.languageiso639-1en-
item.openairetypeJournal Article-
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