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Title: Angiotensin converting enzyme inhibition in heart, kidney, and serum studied ex vivo after administration of zofenopril, captopril, and lisinopril.
Austin Authors: Sun, Y;Mendelsohn, Frederick AO
Affiliation: University of Melbourne, Department of Medicine, Austin Hospital, Heidelberg, Victoria, Australia
Issue Date: 1-Oct-1991
Publication information: Journal of Cardiovascular Pharmacology; 18(4): 478-86
Abstract: Angiotensin converting enzyme inhibition in heart, kidney, and serum were studied ex vivo after oral administration of lisinopril (10 mg/kg), zofenopril (10 mg/kg), and captopril (30 mg/kg) to rats to study the time course, degree, and sites of inhibition of ACE by a quantitative in vitro autoradiography and enzymatic assay. ACE activity in all regions of the heart, kidney, and serum was markedly reduced 4 h after administration of lisinopril and zofenopril and only partially recovered toward control levels at 24 h. After captopril treatment, ACE activity was partially inhibited in heart, kidney, and serum at 1 h and fully recovered toward control levels in most regions at 24 h. These results suggest that these inhibitors reduce ACE in all regions of the heart and kidney without regional selective inhibition. Lisinopril and zofenopril at these doses produced longer-lasting ACE inhibition than captopril. ACE recovery after ACE inhibitor treatment in serum was faster than in heart or kidney.
Gov't Doc #: 1724523
Type: Journal Article
Subjects: Angiotensin-Converting Enzyme Inhibitors.blood.pharmacokinetics.pharmacology
Captopril.analogs & derivatives.pharmacokinetics.pharmacology
Enalapril.analogs & derivatives.pharmacokinetics.pharmacology
Iodine Radioisotopes.diagnostic use
Peptidyl-Dipeptidase A.blood.metabolism
Rats, Inbred Strains
Appears in Collections:Journal articles

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