Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/10272
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dc.contributor.authorPang, Ken Cen
dc.contributor.authorSanders, Megan Ten
dc.contributor.authorMonaco, John Jen
dc.contributor.authorDoherty, Peter Cen
dc.contributor.authorTurner, Stephen Jen
dc.contributor.authorChen, Weisanen
dc.date.accessioned2015-05-15T23:40:33Z
dc.date.available2015-05-15T23:40:33Z
dc.date.issued2006-12-01en
dc.identifier.citationJournal of Immunology (baltimore, Md. : 1950); 177(11): 7680-8en
dc.identifier.govdoc17114438en
dc.identifier.otherPUBMEDen
dc.identifier.urihttp://ahro.austin.org.au/austinjspui/handle/1/10272en
dc.description.abstractPrimary CD8+ T cell (T(CD8+)) responses to viruses are directed toward multiple Ags and shaped by both the level of Ag presentation and the underlying Ag-specific T(CD8+) repertoire. The relative importance of these factors in deciding the hierarchy of T(CD8+) responses and how they are influenced by the immunoproteasome are not well understood. Using an influenza infection model in mice deficient in various immunoproteasome subunits, we observe that Ag presentation and T(CD8+) repertoire are altered in an epitope-specific and immunoproteasome subunit-dependent manner. More importantly, we find that the level of Ag presentation and the extent of the underlying repertoire can work either alone or in concert to determine definitively the magnitude of the individual T(CD8+) responses and hence the overall T(CD8+) hierarchy. Together, these results provide a clearer understanding of how immunodominance hierarchies are established.en
dc.language.isoenen
dc.subject.otherAnimalsen
dc.subject.otherAntigen Presentation.immunologyen
dc.subject.otherBlotting, Westernen
dc.subject.otherCD8-Positive T-Lymphocytes.immunologyen
dc.subject.otherEpitopes, T-Lymphocyte.immunologyen
dc.subject.otherFemaleen
dc.subject.otherMiceen
dc.subject.otherMice, Knockouten
dc.subject.otherOrthomyxoviridae.immunologyen
dc.subject.otherOrthomyxoviridae Infections.immunologyen
dc.subject.otherProteasome Endopeptidase Complex.deficiency.immunologyen
dc.titleImmunoproteasome subunit deficiencies impact differentially on two immunodominant influenza virus-specific CD8+ T cell responses.en
dc.typeJournal Articleen
dc.identifier.journaltitleJournal of Immunology (Baltimore, Md. : 1950)en
dc.identifier.affiliationT Cell Laboratory, Melbourne Centre for Clinical Sciences, Ludwig Institute for Cancer Research, Austin Health, Heidelberg, Victoria 3084, Australiaen
dc.description.pages7680-8en
dc.relation.urlhttps://pubmed.ncbi.nlm.nih.gov/17114438en
dc.type.austinJournal Articleen
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.grantfulltextnone-
item.openairetypeJournal Article-
item.fulltextNo Fulltext-
item.cerifentitytypePublications-
item.languageiso639-1en-
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