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Title: Immunoproteasome subunit deficiencies impact differentially on two immunodominant influenza virus-specific CD8+ T cell responses.
Austin Authors: Pang, Ken C;Sanders, Megan T;Monaco, John J;Doherty, Peter C;Turner, Stephen J;Chen, Weisan
Affiliation: T Cell Laboratory, Melbourne Centre for Clinical Sciences, Ludwig Institute for Cancer Research, Austin Health, Heidelberg, Victoria 3084, Australia
Issue Date: 1-Dec-2006
Publication information: Journal of Immunology (baltimore, Md. : 1950); 177(11): 7680-8
Abstract: Primary CD8+ T cell (T(CD8+)) responses to viruses are directed toward multiple Ags and shaped by both the level of Ag presentation and the underlying Ag-specific T(CD8+) repertoire. The relative importance of these factors in deciding the hierarchy of T(CD8+) responses and how they are influenced by the immunoproteasome are not well understood. Using an influenza infection model in mice deficient in various immunoproteasome subunits, we observe that Ag presentation and T(CD8+) repertoire are altered in an epitope-specific and immunoproteasome subunit-dependent manner. More importantly, we find that the level of Ag presentation and the extent of the underlying repertoire can work either alone or in concert to determine definitively the magnitude of the individual T(CD8+) responses and hence the overall T(CD8+) hierarchy. Together, these results provide a clearer understanding of how immunodominance hierarchies are established.
Gov't Doc #: 17114438
Type: Journal Article
Subjects: Animals
Antigen Presentation.immunology
Blotting, Western
CD8-Positive T-Lymphocytes.immunology
Epitopes, T-Lymphocyte.immunology
Mice, Knockout
Orthomyxoviridae Infections.immunology
Proteasome Endopeptidase Complex.deficiency.immunology
Appears in Collections:Journal articles

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