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Title: Phosphotyrosine signaling in platelets: lessons for vascular thrombosis.
Austin Authors: Wee, Janet L K;Jackson, Denise E
Affiliation: Austin Research Institute, Austin Health, Studley Road, Heidelberg, Victoria 3084, Australia
Issue Date: 1-Oct-2006
Publication information: Current Drug Targets; 7(10): 1265-73
Abstract: Platelet activation is crucial for normal hemostasis to arrest bleeding following vascular injury. However, excessive platelet activation in narrowed atherosclerotic blood vessels that are subject to high shear forces may initiate the onset of arterial thrombosis. When platelets come into contact with, and adhere to collagen exposed by damaged endothelium, they undergo morphological and functional changes necessary to generate a platelet-rich thrombus. This process is complex and involves precise co-ordination of various signaling pathways which lead to firm platelet adhesion to sites of tissue damage, release of granule contents from activated platelets, platelet shape change, platelet aggregation and subsequent thrombus formation and consolidation. Induction of tyrosine phosphorylation of key signaling molecules has emerged as a critical event central to stimulatory signaling pathways that generate platelet activation, but is an essential component associated with regulatory pathways that limit the extent of platelet activation. Understanding mechanisms that regulate platelet activation may contribute to the development of novel therapeutics that control common vascular diseases such as myocardial infarction and ischaemic stroke.
Gov't Doc #: 17073587
Type: Journal Article
Subjects: Animals
Blood Platelets.drug effects.metabolism.physiology
Platelet Activation.drug effects.physiology
Signal Transduction.drug effects.physiology
Thrombosis.drug therapy.metabolism
Appears in Collections:Journal articles

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