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Title: Circulating gastrin is increased in hemochromatosis.
Austin Authors: Smith, Kelly A;Kovac, Suzana;Anderson, Gregory J;Shulkes, Arthur;Baldwin, Graham S
Affiliation: University of Melbourne Department of Surgery, Austin Health, Level 8, Lance Townsend Building, Studley Road, Heidelberg, Vic. 3084, Australia
Issue Date: 18-Oct-2006
Publication information: Febs Letters 2006; 580(26): 6195-8
Abstract: Gastric acid production is important in intestinal iron absorption. The peptide hormone gastrin exists in both amidated and non-amidated forms, which stimulate and potentiate gastric acid secretion, respectively. Since non-amidated gastrins require ferric ions for biological activity in vitro, this study investigated the connection between iron status and gastrin by measurement of circulating gastrin concentrations in mice and humans with hemochromatosis. Gastrin concentrations are increased in the plasma and gastric mucosa of Hfe(-/-) mice, and in the sera of humans with HFE-related hemochromatosis. The discovery of a relationship between iron status and circulating gastrin concentrations opens a new perspective on the mechanisms of iron homeostasis.
Gov't Doc #: 17064691
DOI: 10.1016/j.febslet.2006.10.021
Type: Journal Article
Subjects: Animals
Gastric Mucosa.chemistry
Gastrins.analysis.blood.isolation & purification
Histocompatibility Antigens Class I.genetics
Membrane Proteins.deficiency.genetics
Mice, Knockout
Appears in Collections:Journal articles

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