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Title: | Prophylactic amiodarone for prevention of atrial fibrillation after cardiac surgery: a meta-analysis. | Austin Authors: | Bagshaw, Sean M;Galbraith, P Diane;Mitchell, L Brent;Sauve, Reg;Exner, Derek V;Ghali, William A | Affiliation: | Department of Critical Care Medicine, University of Calgary, Calgary, Alberta, Canada; Department of Community Health Sciences, University of Calgary, Calgary, Alberta, Canada; Department of Intensive Care, Austin Hospital, Melbourne, Victoria, Australia | Issue Date: | 1-Nov-2006 | Publication information: | The Annals of Thoracic Surgery; 82(5): 1927-37 | Abstract: | Amiodarone has been proposed to decrease atrial fibrillation after cardiac surgery. The literature was systematically reviewed for randomized trials comparing amiodarone with control for prevention of atrial fibrillation. Data were extracted on study characteristics, quality, and incidence of atrial fibrillation, cardiovascular outcomes, and length of hospitalization. Nineteen trials were included. Amiodarone reduced the odds ratio of atrial fibrillation (0.50; 95% confidence interval [CI]: 0.43 to 0.59, p < 0.0001), ventricular tachyarrhythmias (0.39; 95% CI: 0.26 to 0.58, p < 0.0001), and strokes (0.53; 95% CI: 0.30 to 0.92, p = 0.02). Amiodarone reduced hospital stay (0.6 days; 95% CI: 0.4 to 0.8, p < 0.0001). Amiodarone decreased atrial fibrillation, reduced perioperative ventricular tachyarrhythmias and strokes, and reduced duration of hospitalization. The current evidence supports recommending the routine use of perioperative amiodarone for cardiac surgery. | Gov't Doc #: | 17062287 | URI: | https://ahro.austin.org.au/austinjspui/handle/1/10254 | DOI: | 10.1016/j.athoracsur.2006.06.032 | Journal: | Annals of Thoracic Surgery | URL: | https://pubmed.ncbi.nlm.nih.gov/17062287 | Type: | Journal Article | Subjects: | Adrenergic beta-Antagonists.therapeutic use Amiodarone.therapeutic use Anti-Arrhythmia Agents.therapeutic use Atrial Fibrillation.epidemiology.etiology.prevention & control Cardiac Surgical Procedures.adverse effects Chemoprevention Humans Incidence Length of Stay Stroke.etiology.prevention & control |
Appears in Collections: | Journal articles |
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