Please use this identifier to cite or link to this item: http://ahro.austin.org.au/austinjspui/handle/1/10254
Title: Prophylactic amiodarone for prevention of atrial fibrillation after cardiac surgery: a meta-analysis.
Authors: Bagshaw, Sean M;Galbraith, P Diane;Mitchell, L Brent;Sauve, Reg;Exner, Derek V;Ghali, William A
Affiliation: Department of Critical Care Medicine, University of Calgary, Calgary, Alberta, Canada; Department of Community Health Sciences, University of Calgary, Calgary, Alberta, Canada; Department of Intensive Care, Austin Hospital, Melbourne, Victoria, Australia.
Issue Date: 1-Nov-2006
Citation: The Annals of Thoracic Surgery; 82(5): 1927-37
Abstract: Amiodarone has been proposed to decrease atrial fibrillation after cardiac surgery. The literature was systematically reviewed for randomized trials comparing amiodarone with control for prevention of atrial fibrillation. Data were extracted on study characteristics, quality, and incidence of atrial fibrillation, cardiovascular outcomes, and length of hospitalization. Nineteen trials were included. Amiodarone reduced the odds ratio of atrial fibrillation (0.50; 95% confidence interval [CI]: 0.43 to 0.59, p < 0.0001), ventricular tachyarrhythmias (0.39; 95% CI: 0.26 to 0.58, p < 0.0001), and strokes (0.53; 95% CI: 0.30 to 0.92, p = 0.02). Amiodarone reduced hospital stay (0.6 days; 95% CI: 0.4 to 0.8, p < 0.0001). Amiodarone decreased atrial fibrillation, reduced perioperative ventricular tachyarrhythmias and strokes, and reduced duration of hospitalization. The current evidence supports recommending the routine use of perioperative amiodarone for cardiac surgery.
Internal ID Number: 17062287
URI: http://ahro.austin.org.au/austinjspui/handle/1/10254
DOI: 10.1016/j.athoracsur.2006.06.032
URL: http://www.ncbi.nlm.nih.gov/pubmed/17062287
Type: Journal Article
Subjects: Adrenergic beta-Antagonists.therapeutic use
Amiodarone.therapeutic use
Anti-Arrhythmia Agents.therapeutic use
Atrial Fibrillation.epidemiology.etiology.prevention & control
Cardiac Surgical Procedures.adverse effects
Chemoprevention
Humans
Incidence
Length of Stay
Stroke.etiology.prevention & control
Appears in Collections:Journal articles

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