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Title: Prophylactic amiodarone for prevention of atrial fibrillation after cardiac surgery: a meta-analysis.
Austin Authors: Bagshaw, Sean M;Galbraith, P Diane;Mitchell, L Brent;Sauve, Reg;Exner, Derek V;Ghali, William A
Affiliation: Department of Critical Care Medicine, University of Calgary, Calgary, Alberta, Canada; Department of Community Health Sciences, University of Calgary, Calgary, Alberta, Canada; Department of Intensive Care, Austin Hospital, Melbourne, Victoria, Australia
Issue Date: 1-Nov-2006
Publication information: The Annals of Thoracic Surgery; 82(5): 1927-37
Abstract: Amiodarone has been proposed to decrease atrial fibrillation after cardiac surgery. The literature was systematically reviewed for randomized trials comparing amiodarone with control for prevention of atrial fibrillation. Data were extracted on study characteristics, quality, and incidence of atrial fibrillation, cardiovascular outcomes, and length of hospitalization. Nineteen trials were included. Amiodarone reduced the odds ratio of atrial fibrillation (0.50; 95% confidence interval [CI]: 0.43 to 0.59, p < 0.0001), ventricular tachyarrhythmias (0.39; 95% CI: 0.26 to 0.58, p < 0.0001), and strokes (0.53; 95% CI: 0.30 to 0.92, p = 0.02). Amiodarone reduced hospital stay (0.6 days; 95% CI: 0.4 to 0.8, p < 0.0001). Amiodarone decreased atrial fibrillation, reduced perioperative ventricular tachyarrhythmias and strokes, and reduced duration of hospitalization. The current evidence supports recommending the routine use of perioperative amiodarone for cardiac surgery.
Gov't Doc #: 17062287
DOI: 10.1016/j.athoracsur.2006.06.032
Journal: Annals of Thoracic Surgery
Type: Journal Article
Subjects: Adrenergic beta-Antagonists.therapeutic use
Amiodarone.therapeutic use
Anti-Arrhythmia Agents.therapeutic use
Atrial Fibrillation.epidemiology.etiology.prevention & control
Cardiac Surgical Procedures.adverse effects
Length of Stay
Stroke.etiology.prevention & control
Appears in Collections:Journal articles

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