Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/10248
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dc.contributor.authorBellomo, Rinaldoen
dc.contributor.authorBagshaw, Sean Men
dc.date.accessioned2015-05-15T23:38:15Z-
dc.date.available2015-05-15T23:38:15Z-
dc.date.issued2006en
dc.identifier.citationCritical Care; 10(5): 232en
dc.identifier.govdoc17029653en
dc.identifier.otherPUBMEDen
dc.identifier.urihttps://ahro.austin.org.au/austinjspui/handle/1/10248en
dc.description.abstractThe current approach to assessing the quality of evidence obtained from clinical trials focuses on three dimensions: the quality of the design (with double-blinded randomised controlled trials representing the highest level of such design); the statistical power (beta) and the level of significance (alpha). While these aspects are important, we argue that other significant aspects of trial quality impinge upon the truthfulness of the findings: biological plausibility, reproducibility and generalisability. We present several recent studies in critical care medicine where the design, beta and alpha components of the study are seemingly satisfactory but where the aspects of biological plausibility, reproducibility and generalisability show serious limitations. Accordingly, we argue for more reflection, definition and consensus on these aspects of the evaluation of evidence.en
dc.language.isoenen
dc.subject.otherEvidence-Based Medicine.classification.methodsen
dc.subject.otherHumansen
dc.subject.otherRandomized Controlled Trials as Topic.classification.methodsen
dc.titleEvidence-based medicine: classifying the evidence from clinical trials--the need to consider other dimensions.en
dc.typeJournal Articleen
dc.identifier.journaltitleCritical Careen
dc.identifier.affiliationDepartment of Intensive Care, Austin Hospital, Studley Rd, Heidelberg, Victoria 3084, Australiaen
dc.identifier.doi10.1186/cc5045en
dc.description.pages232en
dc.relation.urlhttps://pubmed.ncbi.nlm.nih.gov/17029653en
dc.type.austinJournal Articleen
local.name.researcherBellomo, Rinaldo
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.cerifentitytypePublications-
item.fulltextWith Fulltext-
item.grantfulltextopen-
item.languageiso639-1en-
item.openairetypeJournal Article-
crisitem.author.deptIntensive Care-
crisitem.author.deptData Analytics Research and Evaluation (DARE) Centre-
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