Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/10216
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dc.contributor.authorDi Giantomasso, Den
dc.contributor.authorMorimatsu, Hiroshien
dc.contributor.authorBellomo, Rinaldoen
dc.contributor.authorMay, Clive Nen
dc.date.accessioned2015-05-15T23:35:45Z
dc.date.available2015-05-15T23:35:45Z
dc.date.issued2006-08-01en
dc.identifier.citationAnaesthesia and Intensive Care; 34(4): 427-33en
dc.identifier.govdoc16913336en
dc.identifier.otherPUBMEDen
dc.identifier.urihttps://ahro.austin.org.au/austinjspui/handle/1/10216en
dc.description.abstractThe effect of low-dose vasopressin (AVP) on vital regional circulations may be clinically relevant but has not been fully described. We sought to determine the effect of low-dose AVP on systemic haemodynamics, coronary, mesenteric and renal circulations in the conscious normal and septic mammal. We studied seven Merino sheep using a prospective randomized cross-over double-blind placebo-controlled animal design. We inserted flow probes around aorta, coronary, mesenteric and renal arteries and, three weeks later, we infused low-dose AVP (0.02 IU/min) or placebo in the normal and septic state induced by intravenous E. coli. In normal sheep, AVP (0.02 IU/min) induced a 17% decrease in mesenteric blood flow (393.0+/-134.9 vs 472.1+/-163.8 ml/min, P<0.05) and a 14% decrease in mesenteric conductance (P<0.05). In septic sheep, AVP decreased heart rate and cardiac output by 28% and 22%, respectively (P<0.05). It also decreased mesenteric blood flow and mesenteric conductance by 23% (flow: 468.5+/-159.7 vs 611.3+/-136.3 ml/min, P<0.05; conductance: 6.3+/-2.7 vs 8.2+/-2.7 ml/min/mmHg; P<0.05). Renal blood flow was unchanged but urine output and creatinine clearance increased (P<0.05). We conclude that low-dose AVP infusion has similar effects in the normal and septic mammalian circulation: bradycardia, decreased cardiac output, decreased mesenteric blood flow and conductance and increased urine output and creatinine clearance. This information is important to clinicians considering its administration in humans.en
dc.language.isoenen
dc.subject.otherAnimalsen
dc.subject.otherCatheterization, Peripheralen
dc.subject.otherCreatinine.blooden
dc.subject.otherEscherichia coli Infections.physiopathologyen
dc.subject.otherHemodynamics.drug effectsen
dc.subject.otherInfusions, Intravenousen
dc.subject.otherOvariectomyen
dc.subject.otherRegional Blood Flow.drug effectsen
dc.subject.otherRenal Circulation.drug effectsen
dc.subject.otherSepsis.physiopathologyen
dc.subject.otherSheepen
dc.subject.otherSplanchnic Circulation.drug effectsen
dc.subject.otherUrodynamics.drug effectsen
dc.subject.otherVasoconstrictor Agents.administration & dosage.pharmacologyen
dc.subject.otherVasopressins.administration & dosage.pharmacologyen
dc.titleEffect of low-dose vasopressin infusion on vital organ blood flow in the conscious normal and septic sheep.en
dc.typeJournal Articleen
dc.identifier.journaltitleAnaesthesia and Intensive Careen
dc.identifier.affiliationDepartment of Intensive Care, Austin Health, Heidelberg, Victoria, Australiaen
dc.description.pages427-33en
dc.relation.urlhttps://pubmed.ncbi.nlm.nih.gov/16913336en
dc.type.austinJournal Articleen
local.name.researcherBellomo, Rinaldo
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.cerifentitytypePublications-
item.fulltextNo Fulltext-
item.grantfulltextnone-
item.languageiso639-1en-
item.openairetypeJournal Article-
crisitem.author.deptIntensive Care-
crisitem.author.deptData Analytics Research and Evaluation (DARE) Centre-
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