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Title: Regulation of somatostatin secretion by gastrin- and acid-dependent mechanisms.
Austin Authors: Shulkes, Arthur;Read, M A
Affiliation: Department of Surgery, University of Melbourne, Austin Hospital, Victoria, Australia
Issue Date: 1-Nov-1991
Publication information: Endocrinology; 129(5): 2329-34
Abstract: The regulation of gastric somatostatin is linked to changes in gastric acidity, with a number of studies showing a good correlation between somatostatin secretion and gastrin-stimulated luminal acidity. However, gastrin may also have direct effects on somatostatin secretion independent of the concurrent acid status. We have examined the relative contribution of gastrin itself vs. gastric acid on the increase in somatostatin secretion observed after gastrin administration. Pentagastrin administered to conscious sheep for 2 h caused a 10- to 12-fold increase in both portal venous and peripheral jugular venous plasma somatostatin levels. This was associated with a decrease in gastric pH from 3.5 to 1.7. When the sheep were pretreated with the proton pump inhibitor omeprazole to prevent any change in gastric acidity, pentagastrin caused a similar increase in plasma somatostatin. The increase in somatostatin could also be produced by gastrin-17 infusions. Thus, these studies demonstrate that in the conscious animal gastrin can stimulate somatostatin independent of changes in gastric acidity. It is proposed that there is a negative feedback between somatostatin and gastrin, which may modulate the acid secretory response to gastrin.
Gov't Doc #: 1682134
DOI: 10.1210/endo-129-5-2329
Journal: Endocrinology
Type: Journal Article
Subjects: Animals
Chromatography, High Pressure Liquid
Gastric Acid.physiology
Infusions, Intravenous
Jugular Veins
Portal Vein
Appears in Collections:Journal articles

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