Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/10172
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dc.contributor.authorHallam, Karen Ten
dc.contributor.authorOlver, James Sen
dc.contributor.authorChambers, Vanessaen
dc.contributor.authorBegg, Denovan Pen
dc.contributor.authorMcGrath, Carolineen
dc.contributor.authorNorman, Trevor Ren
dc.date.accessioned2015-05-15T23:32:20Z
dc.date.available2015-05-15T23:32:20Z
dc.date.issued2006-08-01en
dc.identifier.citationPsychoneuroendocrinology; 31(7): 867-75en
dc.identifier.govdoc16769177en
dc.identifier.otherPUBMEDen
dc.identifier.urihttp://ahro.austin.org.au/austinjspui/handle/1/10172en
dc.description.abstractThe super-sensitivity of the neurohormone melatonin to light in patients with bipolar disorder provides evidence of the circadian nature of the disorder. This response has been proposed as an endophenotype for identifying people at risk of the disorder and guiding investigations of molecular genetic targets. However, before this response is used as an endophenotypic marker, the heritable nature of melatonin sensitivity in the normal population must be established. The aim of this study was to investigate the heritability of nocturnal melatonin secretion and sensitivity to light in monozygotic and dizygotic twins with no psychiatric history. This study investigated overall melatonin levels (between 2000 and 2400 h) and suppression by 500 lx of light (between 2400 and 0100 h) in 20 pairs of twins (nine monozygotic, 11 dizygotic). The results indicate that melatonin secretion is highly heritable with secretion in one twin being a significant predictor of secretion in their twin in both monozygotic and dizygotic pairs. In relation to light sensitivity, genetic loading appears to play a significant role with the greatest concordance between monozygotic twins, followed by dizygotic twins and finally low concordance in unrelated individuals. This provides additional support for the usefulness of melatonin sensitivity to light as a potential endophenotypic marker of bipolar affective disorder.en
dc.language.isoenen
dc.subject.otherAdolescenten
dc.subject.otherAdulten
dc.subject.otherArea Under Curveen
dc.subject.otherBipolar Disorder.diagnosis.genetics.physiopathologyen
dc.subject.otherCircadian Rhythm.genetics.physiology.radiation effectsen
dc.subject.otherDarknessen
dc.subject.otherDown-Regulation.genetics.physiology.radiation effectsen
dc.subject.otherFemaleen
dc.subject.otherGenetic Loaden
dc.subject.otherHumansen
dc.subject.otherLighten
dc.subject.otherMaleen
dc.subject.otherMelatonin.blood.radiation effects.secretionen
dc.subject.otherPineal Gland.radiation effects.secretionen
dc.subject.otherQuantitative Trait, Heritableen
dc.subject.otherStatistics, Nonparametricen
dc.subject.otherTwins, Dizygotic.blood.geneticsen
dc.subject.otherTwins, Monozygotic.blood.geneticsen
dc.titleThe heritability of melatonin secretion and sensitivity to bright nocturnal light in twins.en
dc.typeJournal Articleen
dc.identifier.journaltitlePsychoneuroendocrinologyen
dc.identifier.affiliationDepartment of Psychiatry, Austin Health, The University of Melbourne, Heidelberg Victoria, Australiaen
dc.identifier.doi10.1016/j.psyneuen.2006.04.004en
dc.description.pages867-75en
dc.relation.urlhttps://pubmed.ncbi.nlm.nih.gov/16769177en
dc.type.austinJournal Articleen
item.fulltextNo Fulltext-
item.openairetypeJournal Article-
item.grantfulltextnone-
item.cerifentitytypePublications-
item.languageiso639-1en-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
crisitem.author.deptPsychiatry (University of Melbourne)-
crisitem.author.deptPsychiatry (University of Melbourne)-
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