| Title |
|
Prophylaxis against venous thrombosis after total hip arthroplasty. |
|
|
| Publication Date |
|
| Author(s) |
|
| Type of document |
|
| Abstract |
|
Venous thrombosis rates were compared in 200 patients undergoing total hip arthroplasty and randomized to receive either fixed mini-dose warfarin (1 mg daily) or adjusted-dose warfarin to maintain an international normalized prothrombin ratio (INR) of 2.0-4.0. Bilateral lower limb venography was performed between days 11 and 13 inclusive. Fixed mini-dose warfarin was associated with a significantly higher rate of total thrombosis (P less than 0.05). General anaesthesia was associated with a significantly higher rate of thrombosis than spinal anaesthesia (P less than 0.05). Adjusted-dose warfarin was associated with more bleeding complications than mini-dose warfarin although these were not attributable to excessive anticoagulation. A single death from pulmonary embolus occurred in the early postoperative period in a patient receiving adjusted-dose warfarin. |
|
|
| Link |
|
| Citation |
|
Australian and New Zealand Journal of Surgery; 62(8): 606-10 |
|
|
| Jornal Title |
|
Australian and New Zealand Journal of Surgery |
|
|
