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Title: Prophylaxis against venous thrombosis after total hip arthroplasty.
Austin Authors: Feller, J A;Parkin, John Desmond;Phillips, G W;Hannon, P J;Hennessy, O F;Huggins, R M
Affiliation: Department of Othopaedic Surgery, Heidelberg Repatriation Hospital, Victoria, Australia
Issue Date: 1-Aug-1992
Publication information: Australian and New Zealand Journal of Surgery; 62(8): 606-10
Abstract: Venous thrombosis rates were compared in 200 patients undergoing total hip arthroplasty and randomized to receive either fixed mini-dose warfarin (1 mg daily) or adjusted-dose warfarin to maintain an international normalized prothrombin ratio (INR) of 2.0-4.0. Bilateral lower limb venography was performed between days 11 and 13 inclusive. Fixed mini-dose warfarin was associated with a significantly higher rate of total thrombosis (P less than 0.05). General anaesthesia was associated with a significantly higher rate of thrombosis than spinal anaesthesia (P less than 0.05). Adjusted-dose warfarin was associated with more bleeding complications than mini-dose warfarin although these were not attributable to excessive anticoagulation. A single death from pulmonary embolus occurred in the early postoperative period in a patient receiving adjusted-dose warfarin.
Gov't Doc #: 1642580
Type: Journal Article
Subjects: Anesthesia, General.statistics & numerical data
Anesthesia, Spinal.statistics & numerical data
Double-Blind Method
Drug Evaluation
Hip Prosthesis.statistics & numerical data
Postoperative Complications.epidemiology.prevention & control.radiography
Regression Analysis
Thrombophlebitis.epidemiology.prevention & control.radiography
Warfarin.administration & dosage
Appears in Collections:Journal articles

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