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Title: Detection of teichoic acid antibodies in Staphylococcus aureus infections.
Austin Authors: Wise, K A;Tosolini, F A
Affiliation: Department of Medical Microbiology, Austin Hospital, Heidelberg, Victoria, Australia
Issue Date: 1-Apr-1992
Publication information: Pathology; 24(2): 102-8
Abstract: A commercially available agar gel diffusion (AGD) assay was used to investigate the teichoic acid antibody (TAA) response in 183 patients with proven Staphylococcus aureus (SA) infections. Two control groups were also investigated. One consisted of 100 hospitalized patients with a variety of medical and surgical conditions other than SA infection and the other consisted of 116 healthy hospital staff members. The sensitivity of the AGD assay varied markedly depending on the site of infection in the patients with proven SA infections. All patients with SA endocarditis developed positive TAA titres (greater than or equal to 1:4), although more than one third of these were initially negative. In patients with chronic osteomyelitis or septic arthritis, 41% had positive TAA titres, whereas no positive titres were detected in patients with acute osteomyelitis or septic arthritis. Lower rates of positive TAA titres were found in patients with deep abscesses (27%), pneumonia (14%) and post-operative infections (9%), but no positive titres occurred in patients with acute uncomplicated bacteremia, cellulitis or meningitis. In 100 hospitalized control patients, no positive titres were detected, and only 1 of 116 (0.9%) healthy hospital staff controls was positive. Suggested guidelines for the use of the AGD assay are discussed.
Gov't Doc #: 1641254
Type: Journal Article
Subjects: Adolescent
Aged, 80 and over
Antibodies, Bacterial.blood
Middle Aged
Reproducibility of Results
Sensitivity and Specificity
Staphylococcal Infections.immunology
Staphylococcus aureus.immunology
Teichoic Acids.immunology
Appears in Collections:Journal articles

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