Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/9996
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dc.contributor.authorSrivastava, Piyush Men
dc.contributor.authorThomas, Merlin Cen
dc.contributor.authorCalafiore, Paulen
dc.contributor.authorMacIsaac, Richard Jen
dc.contributor.authorJerums, Georgeen
dc.contributor.authorBurrell, Louise Men
dc.date.accessioned2015-05-15T23:18:14Z
dc.date.available2015-05-15T23:18:14Z
dc.date.issued2006-01-01en
dc.identifier.citationClinical Science 2006; 110(1): 109-16en
dc.identifier.govdoc16181149en
dc.identifier.otherPUBMEDen
dc.identifier.urihttps://ahro.austin.org.au/austinjspui/handle/1/9996en
dc.description.abstractAnaemia is common in patients with diabetes and associated with an increased risk of diabetic complications. Although the role of anaemia in heart failure is established, we hypothesize that anaemia also contributes to an increased risk of cardiac dysfunction in patients with Type II diabetes. In the present study, 228 consecutive adults with diabetes were investigated using transthoracic echocardiography. Echocardiographic parameters were correlated with the Hb (haemoglobin) level and adjusted for other risk factors for cardiac dysfunction using multivariate analysis. More than one in five patients (23%) had anaemia, which was an independent risk factor for cardiac dysfunction on echocardiography. Over one-third of all patients with evidence of abnormal cardiac function (diastolic and/or systolic dysfunction) on echocardiography had anaemia compared with <5% of patients with normal echocardiographic findings. Most patients with anaemia had cardiac dysfunction (94%), with the major abnormality being diastolic dysfunction associated with an increased left ventricular mass and impaired relaxation indices. A continuous association between diastolic function and Hb was also observed in patients without anaemia. In patients with a history of cardiovascular disease, systolic dysfunction was twice as common in patients with anaemia. Anaemia was also correlated with plasma markers of cardiac risk, including BNP (brain natriuretic peptide), CRP (C-reactive protein) and AVP (arginine vasopressin). Notably, the predictive utility of these markers was eliminated after adjusting for Hb. Consequently, the inexpensive measurement of Hb may be a useful tool to identify diabetic patients at increased risk of cardiac dysfunction.en
dc.language.isoenen
dc.subject.otherAgeden
dc.subject.otherAnemia.blood.complications.physiopathologyen
dc.subject.otherArginine Vasopressin.blooden
dc.subject.otherBiological Markers.blooden
dc.subject.otherC-Reactive Protein.analysisen
dc.subject.otherDiabetes Complications.blood.physiopathologyen
dc.subject.otherDiabetes Mellitus, Type 2.blood.complications.physiopathologyen
dc.subject.otherDiastoleen
dc.subject.otherFemaleen
dc.subject.otherHeart Diseases.etiology.ultrasonographyen
dc.subject.otherHemoglobins.metabolismen
dc.subject.otherHumansen
dc.subject.otherMaleen
dc.subject.otherMiddle Ageden
dc.subject.otherNatriuretic Peptide, Brain.blooden
dc.titleDiastolic dysfunction is associated with anaemia in patients with Type II diabetes.en
dc.typeJournal Articleen
dc.identifier.journaltitleClinical Scienceen
dc.identifier.affiliationDepartment of Medicine, University of Melbourne, Austin Health, Heidelberg, Melbourne, Victoria 3084, Australiaen
dc.identifier.doi10.1042/CS20050184en
dc.description.pages109-16en
dc.relation.urlhttps://pubmed.ncbi.nlm.nih.gov/16181149en
dc.type.austinJournal Articleen
local.name.researcherBurrell, Louise M
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.cerifentitytypePublications-
item.fulltextNo Fulltext-
item.grantfulltextnone-
item.languageiso639-1en-
item.openairetypeJournal Article-
crisitem.author.deptMedicine (University of Melbourne)-
crisitem.author.deptCardiology-
crisitem.author.deptEndocrinology-
crisitem.author.deptCardiology-
crisitem.author.deptGeneral Medicine-
crisitem.author.deptMedicine (University of Melbourne)-
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