Please use this identifier to cite or link to this item: http://ahro.austin.org.au/austinjspui/handle/1/9996
Title: Diastolic dysfunction is associated with anaemia in patients with Type II diabetes.
Authors: Srivastava, Piyush M;Thomas, Merlin C;Calafiore, Paul;MacIsaac, Richard J;Jerums, George;Burrell, Louise M
Affiliation: Department of Medicine, University of Melbourne, Austin Health, Heidelberg, Melbourne, Victoria 3084, Australia
Issue Date: 1-Jan-2006
Citation: Clinical Science (london, England : 1979); 110(1): 109-16
Abstract: Anaemia is common in patients with diabetes and associated with an increased risk of diabetic complications. Although the role of anaemia in heart failure is established, we hypothesize that anaemia also contributes to an increased risk of cardiac dysfunction in patients with Type II diabetes. In the present study, 228 consecutive adults with diabetes were investigated using transthoracic echocardiography. Echocardiographic parameters were correlated with the Hb (haemoglobin) level and adjusted for other risk factors for cardiac dysfunction using multivariate analysis. More than one in five patients (23%) had anaemia, which was an independent risk factor for cardiac dysfunction on echocardiography. Over one-third of all patients with evidence of abnormal cardiac function (diastolic and/or systolic dysfunction) on echocardiography had anaemia compared with <5% of patients with normal echocardiographic findings. Most patients with anaemia had cardiac dysfunction (94%), with the major abnormality being diastolic dysfunction associated with an increased left ventricular mass and impaired relaxation indices. A continuous association between diastolic function and Hb was also observed in patients without anaemia. In patients with a history of cardiovascular disease, systolic dysfunction was twice as common in patients with anaemia. Anaemia was also correlated with plasma markers of cardiac risk, including BNP (brain natriuretic peptide), CRP (C-reactive protein) and AVP (arginine vasopressin). Notably, the predictive utility of these markers was eliminated after adjusting for Hb. Consequently, the inexpensive measurement of Hb may be a useful tool to identify diabetic patients at increased risk of cardiac dysfunction.
Internal ID Number: 16181149
URI: http://ahro.austin.org.au/austinjspui/handle/1/9996
DOI: 10.1042/CS20050184
URL: http://www.ncbi.nlm.nih.gov/pubmed/16181149
Type: Journal Article
Subjects: Aged
Anemia.blood.complications.physiopathology
Arginine Vasopressin.blood
Biological Markers.blood
C-Reactive Protein.analysis
Diabetes Complications.blood.physiopathology
Diabetes Mellitus, Type 2.blood.complications.physiopathology
Diastole
Female
Heart Diseases.etiology.ultrasonography
Hemoglobins.metabolism
Humans
Male
Middle Aged
Natriuretic Peptide, Brain.blood
Appears in Collections:Journal articles

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