Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/9989
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dc.contributor.authorUchino, Shigehikoen
dc.contributor.authorBellomo, Rinaldoen
dc.contributor.authorMorimatsu, Hiroshien
dc.contributor.authorMorgera, Stanislaoen
dc.contributor.authorSchetz, Mieten
dc.contributor.authorTan, Ianen
dc.contributor.authorBouman, Catherineen
dc.contributor.authorMacedo, Ettieneen
dc.contributor.authorGibney, Noelen
dc.contributor.authorTolwani, Ashitaen
dc.contributor.authorDoig, Gordon Sen
dc.contributor.authorOudemans van Straaten, Heleenen
dc.contributor.authorRonco, Claudioen
dc.contributor.authorKellum, John Aen
dc.date.accessioned2015-05-15T23:17:42Z
dc.date.available2015-05-15T23:17:42Z
dc.date.issued2005-09-01en
dc.identifier.citationCritical Care Medicine; 33(9): 1961-7en
dc.identifier.govdoc16148466en
dc.identifier.otherPUBMEDen
dc.identifier.urihttps://ahro.austin.org.au/austinjspui/handle/1/9989en
dc.description.abstractSeveral different severity scoring systems specific to acute renal failure have been proposed. However, most validation studies of these scoring systems were conducted in a single center or in a small number of centers, often the same ones used for their development. Therefore, it is not known whether such severity scoring systems may be widely applied.Prospective clinical investigation.Intensive care units.One thousand seven hundred and forty-two intensive care unit patients with acute renal failure who were either treated with renal replacement therapy or fulfilled predefined criteria.Demographic and clinical information and outcomes were measured.Scores for four acute renal failure-specific scoring systems and two general scoring systems (Simplified Acute Physiology Score II and Sequential Organ Failure Assessment) were calculated, and their discrimination and calibration were tested with receiver operating characteristic curves and Hosmer-Lemeshow goodness-of fit-tests. For the receiver operating characteristic curves, blood lactate levels were also used as a reference. All scores had an area under the receiver operating characteristic curve <0.7 (Mehta 0.670, Liano 0.698, Chertow 0.610, Paganini 0.643, Simplified Acute Physiology Score II 0.645, Sequential Organ Failure Assessment 0.675, lactate 0.639). For scores that can calculate predicted mortality, the Hosmer-Lemeshow goodness-of-fit test showed poor calibration.None of the scoring systems tested had a high level of discrimination or calibration to predict mortality for patients with acute renal failure when tested in a broad cohort of patients from multiple countries. A large, multiple-center database might be needed to improve the discrimination and calibration of acute renal failure scoring system.en
dc.language.isoenen
dc.subject.otherAcute Kidney Injury.diagnosis.therapyen
dc.subject.otherDatabases, Factualen
dc.subject.otherFemaleen
dc.subject.otherHumansen
dc.subject.otherIntensive Care Unitsen
dc.subject.otherLactates.blooden
dc.subject.otherMaleen
dc.subject.otherMiddle Ageden
dc.subject.otherProspective Studiesen
dc.subject.otherROC Curveen
dc.subject.otherRenal Replacement Therapyen
dc.subject.otherSeverity of Illness Indexen
dc.titleExternal validation of severity scoring systems for acute renal failure using a multinational database.en
dc.typeJournal Articleen
dc.identifier.journaltitleCritical Care Medicineen
dc.identifier.affiliationDepartment of Intensive Care, Austin Hospital, Melbourne, Australiaen
dc.description.pages1961-7en
dc.relation.urlhttps://pubmed.ncbi.nlm.nih.gov/16148466en
dc.contributor.corpauthorBeginning and Ending Supportive Therapy for the Kidney (B.E.S.T. Kidney) Investigatorsen
dc.type.austinJournal Articleen
local.name.researcherBellomo, Rinaldo
item.openairetypeJournal Article-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.grantfulltextnone-
item.fulltextNo Fulltext-
item.cerifentitytypePublications-
item.languageiso639-1en-
crisitem.author.deptIntensive Care-
crisitem.author.deptData Analytics Research and Evaluation (DARE) Centre-
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