Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/9986
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dc.contributor.authorLangenberg, Christophen
dc.contributor.authorBellomo, Rinaldoen
dc.contributor.authorMay, Clive Nen
dc.contributor.authorWan, Lien
dc.contributor.authorEgi, Moritokien
dc.contributor.authorMorgera, Stanislaoen
dc.date.accessioned2015-05-15T23:17:29Z
dc.date.available2015-05-15T23:17:29Z
dc.date.issued2005-05-24en
dc.identifier.citationCritical Care 2005; 9(4): R363-74en
dc.identifier.govdoc16137349en
dc.identifier.otherPUBMEDen
dc.identifier.urihttps://ahro.austin.org.au/austinjspui/handle/1/9986en
dc.description.abstractTo assess changes in renal blood flow (RBF) in human and experimental sepsis, and to identify determinants of RBF.Using specific search terms we systematically interrogated two electronic reference libraries to identify experimental and human studies of sepsis and septic acute renal failure in which RBF was measured. In the retrieved studies, we assessed the influence of various factors on RBF during sepsis using statistical methods.We found no human studies in which RBF was measured with suitably accurate direct methods. Where it was measured in humans with sepsis, however, RBF was increased compared with normal. Of the 159 animal studies identified, 99 reported decreased RBF and 60 reported unchanged or increased RBF. The size of animal, technique of measurement, duration of measurement, method of induction of sepsis, and fluid administration had no effect on RBF. In contrast, on univariate analysis, state of consciousness of animals (P = 0.005), recovery after surgery (P < 0.001), haemodynamic pattern (hypodynamic or hyperdynamic state; P < 0.001) and cardiac output (P < 0.001) influenced RBF. However, multivariate analysis showed that only cardiac output remained an independent determinant of RBF (P < 0.001).The impact of sepsis on RBF in humans is unknown. In experimental sepsis, RBF was reported to be decreased in two-thirds of studies (62 %) and unchanged or increased in one-third (38%). On univariate analysis, several factors not directly related to sepsis appear to influence RBF. However, multivariate analysis suggests that cardiac output has a dominant effect on RBF during sepsis, such that, in the presence of a decreased cardiac output, RBF is typically decreased, whereas in the presence of a preserved or increased cardiac output RBF is typically maintained or increased.en
dc.language.isoenen
dc.subject.otherAnimalsen
dc.subject.otherCardiac Outputen
dc.subject.otherDisease Models, Animalen
dc.subject.otherHemodynamicsen
dc.subject.otherHumansen
dc.subject.otherModels, Biologicalen
dc.subject.otherRenal Circulationen
dc.subject.otherSepsis.physiopathologyen
dc.titleRenal blood flow in sepsis.en
dc.typeJournal Articleen
dc.identifier.journaltitleCritical Careen
dc.identifier.affiliationDepartment of Intensive Care, Austin Hospital, and University of Melbourne, Heidelberg, Melbourne, Australiaen
dc.identifier.doi10.1186/cc3540en
dc.description.pagesR363-74en
dc.relation.urlhttps://pubmed.ncbi.nlm.nih.gov/16137349en
dc.type.austinJournal Articleen
local.name.researcherBellomo, Rinaldo
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.cerifentitytypePublications-
item.fulltextWith Fulltext-
item.grantfulltextopen-
item.languageiso639-1en-
item.openairetypeJournal Article-
crisitem.author.deptIntensive Care-
crisitem.author.deptData Analytics Research and Evaluation (DARE) Centre-
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