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Title: Impact of 2-deoxy-2[F-18]fluoro-D-glucose Positron Emission Tomography on the management of patients with advanced melanoma.
Authors: Harris, Marion T;Berlangieri, Salvatore U;Cebon, Jonathan S;Davis, Ian D;Scott, Andrew M
Affiliation: Centre for Positron Emission Tomography, Austin Hospital, Heidelberg, Victoria, Australia
Issue Date: 8-Jul-2005
Citation: Molecular Imaging and Biology : Mib : the Official Publication of the Academy of Molecular Imaging; 7(4): 304-8
Abstract: Accurate staging of patients with melanoma is vital to guide appropriate treatment. 2-Deoxy-2-[F-18]fluoro-D-glucose (FDG)-positron emission tomography (PET) has been reported to be a sensitive and specific technique for the staging of advanced melanoma, however, few studies provide information regarding its impact on patient management.We retrospectively reviewed the FDG-PET scan results of 92 patients with melanoma who had 126 scans performed over a six-year period. These patients were seen at the specialist melanoma clinic at our Institution, and 84 patients (92%) had stage III or IV disease. FDG-PET scan results were correlated with computed tomography (CT) scans and other imaging when available, and with clinical follow-up of a minimum of three to six months. The impact of FDG-PET scans on patient management was also assessed.On a lesion-by-lesion analysis, FDG-PET had a sensitivity of 92%, a specificity of 88%, and an accuracy of 91%. FDG-PET correctly affected the clinical decision-making process in 40 of 126 patient studies (32%), particularly assisting in the selection of patients for surgery.FDG-PET has an important role in guiding the management of patients with advanced melanoma, particularly when surgery is contemplated.
Internal ID Number: 16041590
DOI: 10.1007/s11307-005-0002-7
Type: Journal Article
Subjects: Adult
False Negative Reactions
False Positive Reactions
Fluorodeoxyglucose F18.metabolism
Middle Aged
Neoplasm Staging
Positron-Emission Tomography.methods
Treatment Outcome
Appears in Collections:Journal articles

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