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|Title:||Adenovirus tubulointerstitial nephritis presenting as a renal allograft space occupying lesion.|
|Authors:||Lim, Andy Kim Ho;Parsons, Sarah;Ierino, Francesco L|
|Affiliation:||Department of Nephrology, Austin Health, Studley Road, Heidelberg, Melbourne, Victoria 3084, Australia.|
|Citation:||American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons; 5(8): 2062-6|
|Abstract:||This report describes a case of adenovirus infection in a renal allograft 36 days after transplantation that presented with transient macroscopic hematuria, prominent systemic features and acute renal dysfunction. The patient had persistent high fevers despite broad antibiotic cover. A CT scan demonstrated a new discrete space occupying lesion in the allograft, which was devoid of blood flow on Doppler sonography. A targeted renal biopsy showed florid and focal necrotizing interstitial nephritis with intranuclear tubular viral inclusions. Treatment with ganciclovir and reduction in immunosuppression resulted in a rapid improvement. Immunohistochemistry and electron microscopy confirmed adenovirus infection. This case demonstrates an uncommon presentation of necrotizing adenoviral nephropathy, which should be considered in cases of renal allograft mass lesions.|
|Internal ID Number:||15996261|
|Subjects:||Adenoviridae.isolation & purification|
Adenovirus Infections, Human.pathology
Inclusion Bodies, Viral.pathology
Kidney Tubular Necrosis, Acute.pathology.virology
|Appears in Collections:||Journal articles|
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