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Title: The clinicopathologic basis of Graves' ophthalmopathy: a review.
Authors: Kloprogge, S;Kowal, L;Wall, J;Frauman, Albert G
Affiliation: Molecular Immunology Lab., Clinical Pharmacology and Therapeutics Unit, Department of Medicine, University of Melbourne, Austin Health, Heildeberg, Vic, Australia
Issue Date: 6-May-2005
Citation: European Journal of Ophthalmology; 15(3): 315-23
Abstract: Graves' ophthalmopathy (GO) is a controversial disease, with disagreement within the medical community regarding its pathogenesis, diagnosis, and treatment.We reviewed recent literature on clinical and pathological aspects of GO from both the endocrinologist's and ophthalmologist's perspective.Investigations into the pathogenesis of GO have included possible antigenic targets, orbital cell types, and development of animal models. Diagnosis has been improved recently with new tools and grading systems, but can be complicated by conditions that may simulate one or more of the findings of GO. The new findings of clinical studies also compel practitioners to reassess commonly used GO treatments such as orbital irradiation.Improved understanding of the pathogenic mechanisms of GO should hopefully lead to new diagnostic and therapeutic approaches to this problematic condition.
Internal ID Number: 15944998
Type: Journal Article
Subjects: Animals
Disease Models, Animal
Graves Disease.diagnosis.pathology.therapy
Appears in Collections:Journal articles

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