Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/9886
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dc.contributor.authorNaka, Toshioen
dc.contributor.authorJones, Daryl Aen
dc.contributor.authorBaldwin, Ian Cen
dc.contributor.authorFealy, Nigel Gen
dc.contributor.authorBates, Samanthaen
dc.contributor.authorGoehl, Hermannen
dc.contributor.authorMorgera, Stanislaoen
dc.contributor.authorNeumayer, Hans Hen
dc.contributor.authorBellomo, Rinaldoen
dc.date.accessioned2015-05-15T23:09:39Z
dc.date.available2015-05-15T23:09:39Z
dc.date.issued2005-01-21en
dc.identifier.citationCritical Care 2005; 9(2): R90-5en
dc.identifier.govdoc15774055en
dc.identifier.otherPUBMEDen
dc.identifier.urihttps://ahro.austin.org.au/austinjspui/handle/1/9886en
dc.description.abstractTo test the ability of a novel super high-flux (SHF) membrane with a larger pore size to clear myoglobin from serum.The intensive care unit of a university teaching hospital.A patient with serotonin syndrome complicated by severe rhabodomyolysis and oliguric acute renal failure.Initially continuous veno-venous hemofiltration was performed at 2 l/hour ultrafiltration (UF) with a standard polysulphone 1.4 m2 membrane (cutoff point, 20 kDa), followed by continuous veno-venous hemofiltration with a SHF membrane (cutoff point, 100 kDa) at 2 l/hour UF, then at 3 l/hour UF and then at 4 l/hour UF, in an attempt to clear myoglobin.The myoglobin concentration in the ultrafiltrate at 2 l/hour exchange was at least five times greater with the SHF membrane than with the conventional membrane (>100,000 microg/l versus 23,003 microg/l). The sieving coefficients with the SHF membrane at 3 l/hour UF and 4 l/hour UF were 72.2% and 68.8%, respectively. The amount of myoglobin removed with the conventional membrane was 1.1 g/day compared with 4.4-5.1 g/day for the SHF membrane. The SHF membrane achieved a clearance of up to 56.4 l/day, and achieved a reduction in serum myoglobin concentration from >100,000 microg/l to 16,542 microg/l in 48 hours.SHF hemofiltration achieved a much greater clearance of myoglobin than conventional hemofiltration, and it may provide a potential modality for the treatment of myoglobinuric acute renal failure.en
dc.language.isoenen
dc.subject.otherAcute Kidney Injury.complicationsen
dc.subject.otherFemaleen
dc.subject.otherGlasgow Coma Scaleen
dc.subject.otherHemofiltration.instrumentation.methodsen
dc.subject.otherHospitals, Teachingen
dc.subject.otherHumansen
dc.subject.otherIntensive Care Unitsen
dc.subject.otherMiddle Ageden
dc.subject.otherMyoglobin.blooden
dc.subject.otherMyoglobinuria.therapyen
dc.subject.otherOliguria.complicationsen
dc.subject.otherRhabdomyolysis.therapyen
dc.subject.otherSerotonin Syndrome.complications.diagnosis.therapyen
dc.subject.otherTime Factorsen
dc.titleMyoglobin clearance by super high-flux hemofiltration in a case of severe rhabdomyolysis: a case report.en
dc.typeJournal Articleen
dc.identifier.journaltitleCritical Careen
dc.identifier.affiliationDepartment of Intensive Care, Melbourne University, Austin Hospital, Melbourne, Australiaen
dc.identifier.doi10.1186/cc3034en
dc.description.pagesR90-5en
dc.relation.urlhttps://pubmed.ncbi.nlm.nih.gov/15774055en
dc.type.austinJournal Articleen
local.name.researcherBaldwin, Ian C
item.openairetypeJournal Article-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.grantfulltextopen-
item.fulltextWith Fulltext-
item.cerifentitytypePublications-
item.languageiso639-1en-
crisitem.author.deptIntensive Care-
crisitem.author.deptIntensive Care-
crisitem.author.deptIntensive Care-
crisitem.author.deptIntensive Care-
crisitem.author.deptData Analytics Research and Evaluation (DARE) Centre-
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