Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/9877
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dc.contributor.authorHong, Matthew Kh-
dc.contributor.authorAngus, Peter W-
dc.contributor.authorJones, Robert M-
dc.contributor.authorVaughan, Rhys B-
dc.contributor.authorGow, Paul J-
dc.date.accessioned2015-05-15T23:08:56Z
dc.date.available2015-05-15T23:08:56Z
dc.date.issued2005-04-01-
dc.identifier.citationClinical Transplantation; 19(2): 193-8en_US
dc.identifier.otherPUBMEDen
dc.identifier.urihttps://ahro.austin.org.au/austinjspui/handle/1/9877en
dc.description.abstractRenal dysfunction after liver transplantation is a major management problem. Predictors of improvement in renal dysfunction after calcineurin inhibitor therapy (CNI) withdrawal and replacement with either mycophenolate mofetil (MMF) or azathioprine (AZA) have not previously been examined.Retrospective analysis of 33 post-transplant patients with creatinine clearance (CrCl) below 50 mL/min who were changed from CNI to either MMF or AZA. Following CNI withdrawal patients were divided into two groups: those with improved CrCl after switching and those without, to identify the variables associated with improved renal function.Variables associated with improved CrCl were: absence of hypertension or diabetes, shorter time between transplantation and switch, deterioration in CrCl in months prior to switch and treatment with MMF (compared with AZA).Our findings suggest CNI withdrawal should be targeted to a subgroup of patients whose renal function is most likely to improve.en_US
dc.language.isoenen
dc.subject.otherAzathioprine.therapeutic useen
dc.subject.otherCalcineurin Inhibitorsen
dc.subject.otherCreatinine.blood.urineen
dc.subject.otherDiabetes Complicationsen
dc.subject.otherEnzyme Inhibitors.adverse effectsen
dc.subject.otherFemaleen
dc.subject.otherFollow-Up Studiesen
dc.subject.otherForecastingen
dc.subject.otherGraft Rejection.etiologyen
dc.subject.otherHumansen
dc.subject.otherHypertension.complicationsen
dc.subject.otherIMP Dehydrogenase.antagonists & inhibitorsen
dc.subject.otherImmunosuppressive Agents.adverse effectsen
dc.subject.otherKidney.drug effects.metabolismen
dc.subject.otherKidney Diseases.chemically induced.physiopathologyen
dc.subject.otherLiver Transplantation.adverse effectsen
dc.subject.otherMaleen
dc.subject.otherMiddle Ageden
dc.subject.otherMycophenolic Acid.analogs & derivatives.therapeutic useen
dc.subject.otherPostoperative Complicationsen
dc.subject.otherRetrospective Studiesen
dc.subject.otherSafetyen
dc.subject.otherTime Factorsen
dc.subject.otherTreatment Outcomeen
dc.titlePredictors of improvement in renal function after calcineurin inhibitor withdrawal for post-liver transplant renal dysfunction.en_US
dc.typeJournal Articleen_US
dc.identifier.journaltitleClinical Transplantationen_US
dc.identifier.affiliationVictorian Liver Transplant Uniten_US
dc.identifier.doi10.1111/j.1399-0012.2004.00317.xen_US
dc.description.pages193-8en
dc.relation.urlhttps://pubmed.ncbi.nlm.nih.gov/15740554en
dc.type.contentTexten_US
dc.type.austinJournal Articleen
local.name.researcherAngus, Peter W
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.cerifentitytypePublications-
item.fulltextNo Fulltext-
item.grantfulltextnone-
item.languageiso639-1en-
item.openairetypeJournal Article-
crisitem.author.deptVictorian Liver Transplant Unit-
crisitem.author.deptGastroenterology and Hepatology-
crisitem.author.deptVictorian Liver Transplant Unit-
crisitem.author.deptSurgery (University of Melbourne)-
crisitem.author.deptHepatopancreatobiliary Surgery-
crisitem.author.deptGastroenterology and Hepatology-
crisitem.author.deptGastroenterology and Hepatology-
crisitem.author.deptVictorian Liver Transplant Unit-
crisitem.author.deptGastroenterology and Hepatology-
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