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Title: Predictors of improvement in renal function after calcineurin inhibitor withdrawal for post-liver transplant renal dysfunction.
Authors: Hong, Matthew Kh;Angus, Peter W;Jones, Robert M;Vaughan, Rhys B;Gow, Paul J
Affiliation: Liver Transplant Unit, Austin Hospital, Melbourne, Vic., Australia.
Issue Date: 1-Apr-2005
Citation: Clinical Transplantation; 19(2): 193-8
Abstract: Renal dysfunction after liver transplantation is a major management problem. Predictors of improvement in renal dysfunction after calcineurin inhibitor therapy (CNI) withdrawal and replacement with either mycophenolate mofetil (MMF) or azathioprine (AZA) have not previously been examined.Retrospective analysis of 33 post-transplant patients with creatinine clearance (CrCl) below 50 mL/min who were changed from CNI to either MMF or AZA. Following CNI withdrawal patients were divided into two groups: those with improved CrCl after switching and those without, to identify the variables associated with improved renal function.Variables associated with improved CrCl were: absence of hypertension or diabetes, shorter time between transplantation and switch, deterioration in CrCl in months prior to switch and treatment with MMF (compared with AZA).Our findings suggest CNI withdrawal should be targeted to a subgroup of patients whose renal function is most likely to improve.
Internal ID Number: 15740554
DOI: 10.1111/j.1399-0012.2004.00317.x
Type: Journal Article
Subjects: Azathioprine.therapeutic use
Calcineurin Inhibitors
Diabetes Complications
Enzyme Inhibitors.adverse effects
Follow-Up Studies
Graft Rejection.etiology
IMP Dehydrogenase.antagonists & inhibitors
Immunosuppressive Agents.adverse effects
Kidney.drug effects.metabolism
Kidney Diseases.chemically induced.physiopathology
Liver Transplantation.adverse effects
Middle Aged
Mycophenolic Acid.analogs & derivatives.therapeutic use
Postoperative Complications
Retrospective Studies
Time Factors
Treatment Outcome
Appears in Collections:Journal articles

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