Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/9842
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dc.contributor.authorParker, Francis Cen
dc.contributor.authorStory, David Aen
dc.contributor.authorPoustie, Stephanie Jen
dc.contributor.authorLiu, Guomingen
dc.contributor.authorMcNicol, Larryen
dc.date.accessioned2015-05-15T23:06:09Z
dc.date.available2015-05-15T23:06:09Z
dc.date.issued2004-10-01en
dc.identifier.citationJournal of Cardiothoracic and Vascular Anesthesia; 18(5): 613-9en
dc.identifier.govdoc15578473en
dc.identifier.otherPUBMEDen
dc.identifier.urihttps://ahro.austin.org.au/austinjspui/handle/1/9842en
dc.description.abstractTo determine if anesthesia with sevoflurane or target-controlled propofol reduced the time to tracheal extubation after coronary artery bypass graft surgery compared with isoflurane anesthesia.A 3-arm (isoflurane, sevoflurane, or propofol), randomized, controlled trial with patients and intensive care staff blinded to the drug allocation.A single, tertiary referral hospital affiliated with the University of Melbourne.Three hundred sixty elective coronary artery surgery patients.Patients received either isoflurane (control group, 0.5%-2% end-tidal concentration), sevoflurane (1%-4% end-tidal concentration), or target-controlled infusion of propofol (1-8 microg/mL plasma target concentration) as part of a balanced, standardized anesthetic technique including 15 microg/kg of fentanyl.The primary outcome was time to tracheal extubation. The median time to tracheal extubation for the propofol group was 10.25 hours (interquartile range [IQR] 8.08-12.75), the sevoflurane group 9.17 hours (IQR 6.25-11.25), and the isoflurane group 7.67 hours (IQR 6.25-9.42). Intraoperatively, the propofol group required less vasopressor (p = 0.002) and more vasodilator therapy (nitroglycerin p = 0.01, nitroprusside p = 0.002). There was no difference among the groups in time to intensive care unit discharge.The median time to tracheal extubation was significantly longer for the target-controlled propofol group. A significantly greater number in this group required the use of a vasodilator to control intraoperative hypertension.en
dc.language.isoenen
dc.subject.otherAgeden
dc.subject.otherAnalgesics.therapeutic useen
dc.subject.otherAnesthetics, Inhalation.therapeutic useen
dc.subject.otherAnesthetics, Intravenous.blood.therapeutic useen
dc.subject.otherCoronary Artery Bypass.methodsen
dc.subject.otherFemaleen
dc.subject.otherHemodynamics.drug effectsen
dc.subject.otherHumansen
dc.subject.otherIntensive Care Unitsen
dc.subject.otherIntubation, Intratracheal.methods.statistics & numerical dataen
dc.subject.otherIsoflurane.therapeutic useen
dc.subject.otherLength of Stay.statistics & numerical dataen
dc.subject.otherMaleen
dc.subject.otherMethyl Ethers.therapeutic useen
dc.subject.otherMiddle Ageden
dc.subject.otherPostoperative Perioden
dc.subject.otherPropofol.blood.therapeutic useen
dc.subject.otherProspective Studiesen
dc.subject.otherTime Factorsen
dc.subject.otherTreatment Outcomeen
dc.subject.otherVasodilator Agents.therapeutic useen
dc.titleTime to tracheal extubation after coronary artery surgery with isoflurane, sevoflurane, or target-controlled propofol anesthesia: a prospective, randomized, controlled trial.en
dc.typeJournal Articleen
dc.identifier.journaltitleJournal of Cardiothoracic and Vascular Anesthesiaen
dc.identifier.affiliationDepartment of Anaesthesia, Austin Health, Heidelberg, Victoria, Australiaen
dc.description.pages613-9en
dc.relation.urlhttps://pubmed.ncbi.nlm.nih.gov/15578473en
dc.type.austinJournal Articleen
local.name.researcherStory, David A
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.cerifentitytypePublications-
item.fulltextNo Fulltext-
item.grantfulltextnone-
item.languageiso639-1en-
item.openairetypeJournal Article-
crisitem.author.deptAnaesthesia-
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