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|Title:||Short peptide sequences containing MHC class I and/or class II epitopes linked to nano-beads induce strong immunity and inhibition of growth of antigen-specific tumour challenge in mice.|
|Authors:||Fifis, Theodora;Mottram, Patricia;Bogdanoska, Violeta;Hanley, Jennifer;Plebanski, Magdalena|
|Affiliation:||Vaccine Development and Infectious Diseases Unit, Austin Research Institute, Austin Hospital, Studley Road, Heidelberg 3084, Vic., Australia.|
|Citation:||Vaccine; 23(2): 258-66|
|Abstract:||Peptide based vaccines offer practical advantages, but unmodified peptides usually require an adjuvant or delivery vehicle to promote immunogenicity. When peptides containing ovalbumin (OVA) derived CD4 and CD8 T cell epitopes were conjugated to 0.05 microm nano-beads, they gave strong immune responses and inhibition of growth of tumour cells expressing the CD8 T cell epitope with MHC class I. These responses were inducible with both high (50 microg) and low (5 microg) peptide doses after a single immunisation. The helper CD4 T cell epitope was unnecessary for induction of CD8 T cell or tumour challenge responses. However, the CD4 T cell epitope contained a B cell epitope and triggered strong antibody responses. This simple approach offers a convenient experimental tool and a potentially useful clinical method for peptide immunisation.|
|Internal ID Number:||15531045|
Histocompatibility Antigens Class I.chemistry.pharmacology
Histocompatibility Antigens Class II.chemistry.pharmacology
Mice, Inbred C57BL
Vaccines, Conjugate.administration & dosage.immunology
Vaccines, Synthetic.administration & dosage.immunology
|Appears in Collections:||Journal articles|
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