Please use this identifier to cite or link to this item: http://ahro.austin.org.au/austinjspui/handle/1/9827
Title: Short peptide sequences containing MHC class I and/or class II epitopes linked to nano-beads induce strong immunity and inhibition of growth of antigen-specific tumour challenge in mice.
Authors: Fifis, Theodora;Mottram, Patricia;Bogdanoska, Violeta;Hanley, Jennifer;Plebanski, Magdalena
Affiliation: Vaccine Development and Infectious Diseases Unit, Austin Research Institute, Austin Hospital, Studley Road, Heidelberg 3084, Vic., Australia.
Issue Date: 25-Nov-2004
Citation: Vaccine; 23(2): 258-66
Abstract: Peptide based vaccines offer practical advantages, but unmodified peptides usually require an adjuvant or delivery vehicle to promote immunogenicity. When peptides containing ovalbumin (OVA) derived CD4 and CD8 T cell epitopes were conjugated to 0.05 microm nano-beads, they gave strong immune responses and inhibition of growth of tumour cells expressing the CD8 T cell epitope with MHC class I. These responses were inducible with both high (50 microg) and low (5 microg) peptide doses after a single immunisation. The helper CD4 T cell epitope was unnecessary for induction of CD8 T cell or tumour challenge responses. However, the CD4 T cell epitope contained a B cell epitope and triggered strong antibody responses. This simple approach offers a convenient experimental tool and a potentially useful clinical method for peptide immunisation.
Internal ID Number: 15531045
URI: http://ahro.austin.org.au/austinjspui/handle/1/9827
DOI: 10.1016/j.vaccine.2004.05.022
URL: http://www.ncbi.nlm.nih.gov/pubmed/15531045
Type: Journal Article
Subjects: Animals
Antigens, Neoplasm
Epitopes.chemistry.immunology.pharmacology
Histocompatibility Antigens Class I.chemistry.pharmacology
Histocompatibility Antigens Class II.chemistry.pharmacology
Mice
Mice, Inbred C57BL
Nanotechnology
Peptides.chemical synthesis.chemistry.immunology.pharmacology
T-Lymphocytes.drug effects.immunology
Vaccines, Conjugate.administration & dosage.immunology
Vaccines, Synthetic.administration & dosage.immunology
Appears in Collections:Journal articles

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