Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/9819
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dc.contributor.authorGamvrellis, Anitaen
dc.contributor.authorLeong, Daviden
dc.contributor.authorHanley, Jennifer Cen
dc.contributor.authorXiang, Sue Den
dc.contributor.authorMottram, Patriciaen
dc.contributor.authorPlebanski, Magdalenaen
dc.date.accessioned2015-05-15T23:04:21Z
dc.date.available2015-05-15T23:04:21Z
dc.date.issued2004-10-01en
dc.identifier.citationImmunology and Cell Biology; 82(5): 506-16en
dc.identifier.govdoc15479436en
dc.identifier.otherPUBMEDen
dc.identifier.urihttps://ahro.austin.org.au/austinjspui/handle/1/9819en
dc.description.abstractAlthough vaccines have been highly successful in preventing and treating many infectious diseases (including smallpox, polio and diphtheria) diseases prevalent in the developing world such as malaria and HIV, that suppress the host immune system, require new, multiple strategies that will be defined by our growing understanding of specific immune activation. The definition of adjuvants, previously thought of as any substance that enhanced the immunogenicity of antigen, could now include soluble mediators and antigenic carriers that interact with surface molecules present on DC (e.g. LPS, Flt3L, heat shock protein) particulate antigens which are taken up by mechanisms available to APC but not other cell types (e.g. immunostimulatory complexes, latex, polystyrene particles) and viral/bacterial vectors that infect antigen presenting cells (e.g. vaccinia, lentivirus, adenovirus). These approaches, summarized herein, have shown potential in vaccinating against disease in animal models, and in some cases in humans. Of these, particle-antigen conjugates provide rapid formulation of the vaccine, easy storage and wide application, with both carrier and adjuvant functions that activate DC. Combined vaccines of the future could use adjuvants such as virus-like particles and particles targeted towards a predominant cellular type or immune response, with target cell activation enhanced by growth factors or maturation signals prior to, or during immunization. Collectively, these new additions to adjuvant technology provide opportunities for more specific immune regulation than previously available.en
dc.language.isoenen
dc.subject.otherAdjuvants, Immunologicen
dc.subject.otherAntigens.immunologyen
dc.subject.otherDendritic Cells.immunologyen
dc.subject.otherHumansen
dc.subject.otherVaccines.immunologyen
dc.titleVaccines that facilitate antigen entry into dendritic cells.en
dc.typeJournal Articleen
dc.identifier.journaltitleImmunology and cell biologyen
dc.identifier.affiliationVaccine Development and Infectious Diseases Unit, The Austin Research Institute, Austin Hospital, Studley Road, Heidelberg, Victoria 3084, Australiaen
dc.identifier.doi10.1111/j.0818-9641.2004.01271.xen
dc.description.pages506-16en
dc.relation.urlhttps://pubmed.ncbi.nlm.nih.gov/15479436en
dc.type.austinJournal Articleen
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.cerifentitytypePublications-
item.fulltextNo Fulltext-
item.grantfulltextnone-
item.languageiso639-1en-
item.openairetypeJournal Article-
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