Please use this identifier to cite or link to this item: http://ahro.austin.org.au/austinjspui/handle/1/9819
Title: Vaccines that facilitate antigen entry into dendritic cells.
Authors: Gamvrellis, Anita;Leong, David;Hanley, Jennifer C;Xiang, Sue D;Mottram, Patricia;Plebanski, Magdalena
Affiliation: Vaccine Development and Infectious Diseases Unit, The Austin Research Institute, Austin Hospital, Studley Road, Heidelberg, Victoria 3084, Australia.
Issue Date: 1-Oct-2004
Citation: Immunology and Cell Biology; 82(5): 506-16
Abstract: Although vaccines have been highly successful in preventing and treating many infectious diseases (including smallpox, polio and diphtheria) diseases prevalent in the developing world such as malaria and HIV, that suppress the host immune system, require new, multiple strategies that will be defined by our growing understanding of specific immune activation. The definition of adjuvants, previously thought of as any substance that enhanced the immunogenicity of antigen, could now include soluble mediators and antigenic carriers that interact with surface molecules present on DC (e.g. LPS, Flt3L, heat shock protein) particulate antigens which are taken up by mechanisms available to APC but not other cell types (e.g. immunostimulatory complexes, latex, polystyrene particles) and viral/bacterial vectors that infect antigen presenting cells (e.g. vaccinia, lentivirus, adenovirus). These approaches, summarized herein, have shown potential in vaccinating against disease in animal models, and in some cases in humans. Of these, particle-antigen conjugates provide rapid formulation of the vaccine, easy storage and wide application, with both carrier and adjuvant functions that activate DC. Combined vaccines of the future could use adjuvants such as virus-like particles and particles targeted towards a predominant cellular type or immune response, with target cell activation enhanced by growth factors or maturation signals prior to, or during immunization. Collectively, these new additions to adjuvant technology provide opportunities for more specific immune regulation than previously available.
Internal ID Number: 15479436
URI: http://ahro.austin.org.au/austinjspui/handle/1/9819
DOI: 10.1111/j.0818-9641.2004.01271.x
URL: http://www.ncbi.nlm.nih.gov/pubmed/15479436
Type: Journal Article
Subjects: Adjuvants, Immunologic
Antigens.immunology
Dendritic Cells.immunology
Humans
Vaccines.immunology
Appears in Collections:Journal articles

Files in This Item:
There are no files associated with this item.


Items in AHRO are protected by copyright, with all rights reserved, unless otherwise indicated.