Please use this identifier to cite or link to this item: http://ahro.austin.org.au/austinjspui/handle/1/9804
Title: Effect of prior cognitive state on resting state networks measured with functional connectivity.
Authors: Waites, Anthony B;Stanislavsky, Alexandra;Abbott, David F;Jackson, Graeme D
Affiliation: Brain Research Institute, Austin Health, Heidelberg West, Australia.
Issue Date: 1-Jan-2005
Citation: Human Brain Mapping; 24(1): 59-68
Abstract: To address the extent to which functional connectivity measures an absolute brain state, we observed the effect of prior performance of a language task on resting-state networks in regions associated with language. Six subjects were imaged during rest before and after a block-design language task. Connectivity maps were generated for each of four language regions (identified from analysis of the language activation portion of the study) in each subject for both rest periods. Conjunction analysis demonstrated distinct networks of voxels for each seed region, indicating separate functional subnetworks associated with the different regions. In a comparison of rest before and after the activation task widespread and significant changes were observed in all individuals, suggesting that the measured resting state network reflects a dynamic image of the current brain state. At the group level, an extended network was observed that was largely persistent over time. Even at the group level an increase in connectivity was observed between left and right middle frontal gyri, and between posterior cingulate cortex and medial frontal cortex in the rest after the language task. These results suggest that functional connectivity may be a powerful measure of cognitive state, sensitive to differences between controls and patients together with the particular cognitive processing occurring during the rest state.
Internal ID Number: 15382248
URI: http://ahro.austin.org.au/austinjspui/handle/1/9804
DOI: 10.1002/hbm.20069
URL: http://www.ncbi.nlm.nih.gov/pubmed/15382248
Type: Journal Article
Subjects: Brain Mapping
Cerebral Cortex.anatomy & histology.physiology
Cognition.physiology
Female
Functional Laterality.physiology
Humans
Language
Language Tests
Magnetic Resonance Imaging
Male
Nerve Net.anatomy & histology.physiology
Neural Pathways.anatomy & histology.physiology
Time Factors
Verbal Behavior.physiology
Appears in Collections:Journal articles

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