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https://ahro.austin.org.au/austinjspui/handle/1/9795
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DC Field | Value | Language |
---|---|---|
dc.contributor.author | Fifis, Theodora | en |
dc.contributor.author | Gamvrellis, Anita | en |
dc.contributor.author | Crimeen-Irwin, Blessing | en |
dc.contributor.author | Pietersz, Geoffrey A | en |
dc.contributor.author | Li, Jie | en |
dc.contributor.author | Mottram, Patricia L | en |
dc.contributor.author | McKenzie, Ian F C | en |
dc.contributor.author | Plebanski, Magdalena | en |
dc.date.accessioned | 2015-05-15T23:02:18Z | |
dc.date.available | 2015-05-15T23:02:18Z | |
dc.date.issued | 2004-09-01 | en |
dc.identifier.citation | Journal of Immunology (baltimore, Md. : 1950); 173(5): 3148-54 | en |
dc.identifier.govdoc | 15322175 | en |
dc.identifier.other | PUBMED | en |
dc.identifier.uri | https://ahro.austin.org.au/austinjspui/handle/1/9795 | en |
dc.description.abstract | Infection can protect against subsequent disease by induction of both humoral and cellular immunity, but inert protein-based vaccines are not as effective. In this study, we present a new vaccine design, with Ag covalently conjugated to solid core nano-beads of narrowly defined size (0.04-0.05 microm) that localize to dendritic cells (DEC205(+) CD40(+), CD86(+)) in draining lymph nodes, inducing high levels of IFN-gamma production (CD8 T cells: precursor frequencies 1/5000 to 1/1000) and high Ab titers in mice. Conjugation of Ag to these nano-beads induced responses that were significantly higher (2- to 10-fold) than those elicited by other bead sizes, and higher than a range of currently used adjuvants (alum, QuilA, monophosphoryl lipid A). Responses were comparable to CFA/IFA immunization for Abs and ex vivo peptide-pulsed dendritic cell immunization for CD8 T cells. A single dose of Ag-conjugated beads protected mice from tumors in two different model challenges and caused rapid clearance of established tumors in mice. Thus, a range of Ags conjugated to nano-beads was effective as immunogens in both therapeutic and prophylactic scenarios. | en |
dc.language.iso | en | en |
dc.subject.other | Adjuvants, Immunologic.pharmacology | en |
dc.subject.other | Animals | en |
dc.subject.other | Antigens.immunology | en |
dc.subject.other | Cancer Vaccines.immunology.pharmacology | en |
dc.subject.other | Disease Models, Animal | en |
dc.subject.other | Mice | en |
dc.subject.other | Nanotechnology | en |
dc.subject.other | Nanotubes | en |
dc.subject.other | Neoplasms.drug therapy.immunology.prevention & control | en |
dc.title | Size-dependent immunogenicity: therapeutic and protective properties of nano-vaccines against tumors. | en |
dc.type | Journal Article | en |
dc.identifier.journaltitle | Journal of Immunology (Baltimore, Md. : 1950) | en |
dc.identifier.affiliation | Austin Research Institute, Austin Hospital, Heidelberg, Victoria, Australia | en |
dc.description.pages | 3148-54 | en |
dc.relation.url | https://pubmed.ncbi.nlm.nih.gov/15322175 | en |
dc.type.austin | Journal Article | en |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.cerifentitytype | Publications | - |
item.fulltext | No Fulltext | - |
item.grantfulltext | none | - |
item.languageiso639-1 | en | - |
item.openairetype | Journal Article | - |
Appears in Collections: | Journal articles |
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