Please use this identifier to cite or link to this item: http://ahro.austin.org.au/austinjspui/handle/1/9785
Title: Complications and failure of anticoagulation therapy in the treatment of venous thromboembolism in patients with disseminated malignancy.
Authors: Chan, A;Woodruff, R K
Affiliation: Austin Hospital, Heidelberg, Vic.
Issue Date: 1-Apr-1992
Citation: Australian and New Zealand Journal of Medicine; 22(2): 119-22
Abstract: Thirty-one patients with malignancy, anticoagulated for the treatment of venous thromboembolism (VTE) are reported. Complications of treatment included major bleeding (35%), redevelopment of VTE whilst on therapeutic levels of anticoagulants (13%) and recurrent VTE following cessation of anticoagulant (42%). Forty-two per cent of patients died within three months of initiating anticoagulant therapy. The cause of death was progressive malignancy, except in one patient who died of anticoagulant-related bleeding. The high incidence of bleeding is frequently associated with over-anticoagulation and indicates the need for improved monitoring. The frequent recurrence of VTE is associated with chronic disseminated intravascular coagulation, for which warfarin is ineffective and heparin is indicated.
Internal ID Number: 1530532
URI: http://ahro.austin.org.au/austinjspui/handle/1/9785
URL: http://www.ncbi.nlm.nih.gov/pubmed/1530532
Type: Journal Article
Subjects: Adult
Aged
Female
Hemorrhage.chemically induced
Heparin.adverse effects
Humans
Male
Middle Aged
Monitoring, Physiologic
Neoplasms.complications
Recurrence
Thromboembolism.drug therapy.etiology
Thrombophlebitis.drug therapy.etiology
Treatment Outcome
Warfarin.adverse effects
Appears in Collections:Journal articles

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