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|Title:||Complications and failure of anticoagulation therapy in the treatment of venous thromboembolism in patients with disseminated malignancy.|
|Authors:||Chan, A;Woodruff, R K|
|Affiliation:||Austin Hospital, Heidelberg, Vic.|
|Citation:||Australian and New Zealand Journal of Medicine; 22(2): 119-22|
|Abstract:||Thirty-one patients with malignancy, anticoagulated for the treatment of venous thromboembolism (VTE) are reported. Complications of treatment included major bleeding (35%), redevelopment of VTE whilst on therapeutic levels of anticoagulants (13%) and recurrent VTE following cessation of anticoagulant (42%). Forty-two per cent of patients died within three months of initiating anticoagulant therapy. The cause of death was progressive malignancy, except in one patient who died of anticoagulant-related bleeding. The high incidence of bleeding is frequently associated with over-anticoagulation and indicates the need for improved monitoring. The frequent recurrence of VTE is associated with chronic disseminated intravascular coagulation, for which warfarin is ineffective and heparin is indicated.|
|Internal ID Number:||1530532|
|Appears in Collections:||Journal articles|
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