Please use this identifier to cite or link to this item: http://ahro.austin.org.au/austinjspui/handle/1/9765
Title: Gastrins, cholecystokinins and gastrointestinal cancer.
Authors: Aly, Ahmad;Shulkes, Arthur;Baldwin, Graham S
Affiliation: Department of Surgery, University of Melbourne, Austin Campus, A and RMC, Studley Road, Heidelberg, Melbourne, Victoria 3084, Australia.
Issue Date: 6-Jul-2004
Citation: Biochimica Et Biophysica Acta; 1704(1): 1-10
Abstract: The gastrointestinal peptide hormones gastrin and cholecystokinin (CCK) are well known for their ability to stimulate gastric acid secretion and pancreatic enzyme secretion, respectively. The suggestion that gastrin and CCK might also promote the development of cancers of the gastrointestinal tract has been controversial, but an increasing body of evidence now supports the view that the amidated and non-amidated forms of gastrin act as growth factors via different receptors in different regions of the gut. For example, animal experiments indicate that amidated gastrins are involved in cellular differentiation and repair in the gastric mucosa, and synergize with Helicobacter pylori infection in the development of gastric carcinoma. In contrast, non-amidated gastrins stimulate colonic mucosal growth, accelerate the early steps in colorectal carcinoma formation, and are elevated in the tumour and circulation of patients with colorectal cancer. Although human pancreatic carcinomas express CCK-1 and CCK-2 receptors, the role of gastrins and CCK in pancreatic carcinogenesis is yet to be established. Further investigation of the possible role of the CCK-2 receptor in gastric and pancreatic neoplasia, and of the hypothesis that gastrin precursors act as autocrine growth factors in colorectal carcinoma, is warranted. However, therapies aimed at the gastrins must be targeted to the relevant gastrin/gastrin receptor combination.
Internal ID Number: 15238241
URI: http://ahro.austin.org.au/austinjspui/handle/1/9765
DOI: 10.1016/j.bbcan.2004.01.004
URL: http://www.ncbi.nlm.nih.gov/pubmed/15238241
Type: Journal Article
Subjects: Cholecystokinin.physiology
Colorectal Neoplasms.etiology
Gastrins.physiology
Gastrointestinal Neoplasms.etiology
Humans
Pancreatic Neoplasms.etiology
Receptors, Cholecystokinin.metabolism
Stomach Neoplasms.etiology
Tumor Cells, Cultured
Appears in Collections:Journal articles

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