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|Title:||Is benign rolandic epilepsy genetically determined?|
|Authors:||Vadlamudi, Lata;Harvey, A Simon;Connellan, Mary M;Milne, Roger L;Hopper, John L;Scheffer, Ingrid E;Berkovic, Samuel F|
|Affiliation:||Epilepsy Research Centre, Department of Medicine (Neurology), University of Melbourne, Austin Health, Australia.|
|Citation:||Annals of Neurology; 56(1): 129-32|
|Abstract:||Benign rolandic epilepsy (BRE) is considered to be a genetically determined idiopathic partial epilepsy. We studied twins with BRE and compared the concordance with a twin sample of idiopathic generalized epilepsy (IGE). All eight BRE pairs (six monozygous [MZ], two dizygous [DZ]) were discordant. MZ pairwise concordance was 0 (95% confidence interval [CI], 0-0.4) for BRE compared with 0.7 (95% CI, 0.5-0.9) for 26 IGE MZ pairs. Our data suggest that conventional genetic influences in BRE are considerably less than for IGE, and other mechanisms need to be explored.|
|Internal ID Number:||15236411|
|Appears in Collections:||Journal articles|
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