Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/9739
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dc.contributor.authorCooper, Mark Een
dc.contributor.authorRumble, J Ren
dc.contributor.authorAllen, Terri Jen
dc.contributor.authorO'Brien, R Cen
dc.contributor.authorJerums, Georgeen
dc.contributor.authorDoyle, A Een
dc.date.accessioned2015-05-15T22:56:35Z
dc.date.available2015-05-15T22:56:35Z
dc.date.issued1992-04-01en
dc.identifier.citationKidney International; 41(4): 898-903en
dc.identifier.govdoc1513111en
dc.identifier.otherPUBMEDen
dc.identifier.urihttps://ahro.austin.org.au/austinjspui/handle/1/9739en
dc.description.abstractWe have compared the effects of the angiotensin converting enzyme inhibitor, perindopril, and a conventional antihypertensive regimen (triple therapy: hydralazine, reserpine and hydrochlorothiazide) on kidney function and albuminuria in hypertensive diabetic rats. Diabetes was induced with streptozotocin in spontaneously hypertensive (SHR) rats and they were randomized to receive no treatment, perindopril or triple therapy. Antihypertensive drugs were commenced at the time of induction of diabetes and continued for 16 weeks. Blood pressure reduction was equal in the groups treated with perindopril or triple therapy. All groups had similar severity of diabetes as determined by body weight, serum glucose and glycated hemoglobin levels. Whereas plasma renin activity rose in both the perindopril and triple therapy groups, it is likely that the effects on angiotensin II levels were opposite since perindopril but not triple therapy was associated with a significant reduction in plasma angiotensin converting enzyme activity. Diabetes was associated with an increase in glomerular filtration rate. At 12 weeks, glomerular filtration rate was higher in the perindopril treated group when compared to the triple therapy group, but neither group treated with antihypertensive therapy was different to untreated diabetic rats. Both drug regimens reduced albuminuria in the diabetic rats to a similar degree apparently independently of their effects on the renin-angiotensin system. Studies in diabetic subjects are warranted to evaluate different classes of antihypertensive drugs with respect to their effects on kidney function, proteinuria and glomerular morphology.en
dc.language.isoenen
dc.subject.otherAlbuminuria.urineen
dc.subject.otherAngiotensin-Converting Enzyme Inhibitors.pharmacologyen
dc.subject.otherAnimalsen
dc.subject.otherAntihypertensive Agents.therapeutic useen
dc.subject.otherBlood Glucose.analysisen
dc.subject.otherBlood Pressure.drug effectsen
dc.subject.otherDiabetes Mellitus, Experimental.complications.metabolismen
dc.subject.otherDrug Combinationsen
dc.subject.otherGlomerular Filtration Rate.drug effectsen
dc.subject.otherHydralazine.pharmacologyen
dc.subject.otherHydrochlorothiazide.pharmacologyen
dc.subject.otherHypertension.complicationsen
dc.subject.otherIndoles.pharmacologyen
dc.subject.otherMaleen
dc.subject.otherPerindoprilen
dc.subject.otherRatsen
dc.subject.otherRats, Inbred SHRen
dc.subject.otherRenin-Angiotensin System.drug effectsen
dc.subject.otherReserpine.pharmacologyen
dc.titleAntihypertensive therapy in a model combining spontaneous hypertension with diabetes.en
dc.typeJournal Articleen
dc.identifier.journaltitleKidney Internationalen
dc.identifier.affiliationDepartment of Medicine, University of Melbourne, Austin Hospital, Heidelberg, Victoria, Australiaen
dc.description.pages898-903en
dc.relation.urlhttps://pubmed.ncbi.nlm.nih.gov/1513111en
dc.type.austinJournal Articleen
local.name.researcherJerums, George
item.openairetypeJournal Article-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.grantfulltextnone-
item.fulltextNo Fulltext-
item.cerifentitytypePublications-
item.languageiso639-1en-
crisitem.author.deptEndocrinology-
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