Please use this identifier to cite or link to this item: http://ahro.austin.org.au/austinjspui/handle/1/9732
Title: ACE2, a new regulator of the renin-angiotensin system.
Authors: Burrell, Louise M;Johnston, Colin I;Tikellis, Christos;Cooper, Mark E
Affiliation: Department of Medicine, University of Melbourne, Austin Health, Heidelberg Heights 3081, Australia. l.burrell@unimelb.edu.au
Issue Date: 6-May-2004
Citation: Trends in Endocrinology and Metabolism: Tem; 15(4): 166-9
Abstract: Angiotensin-converting enzyme (ACE) is a zinc metalloproteinase and a key regulator of the renin-angiotensin system (RAS). ACE2 is a newly described enzyme identified in rodents and humans with a more restricted distribution than ACE, and is found mainly in heart and kidney. ACE2 cleaves a single residue from angiotensin I (Ang I) to generate Ang 1-9, and degrades Ang II, the main effector of the RAS, to the vasodilator Ang 1-7. The importance of ACE2 in normal physiology and pathophysiological states is largely unknown. ACE2 might act in a counter-regulatory manner to ACE, modulating the balance between vasoconstrictors and vasodilators within the heart and kidney, and playing a significant role in regulating cardiovascular and renal function.
Internal ID Number: 15109615
URI: http://ahro.austin.org.au/austinjspui/handle/1/9732
DOI: 10.1016/j.tem.2004.03.001
URL: http://www.ncbi.nlm.nih.gov/pubmed/15109615
Type: Journal Article
Subjects: Animals
Carboxypeptidases.metabolism.physiology
Heart.physiology
Humans
Hypertension.physiopathology
Kidney.enzymology.physiology
Myocardium.enzymology
Peptidyl-Dipeptidase A.metabolism.physiology
Renin-Angiotensin System.physiology
Tissue Distribution
Appears in Collections:Journal articles

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