Please use this identifier to cite or link to this item: http://ahro.austin.org.au/austinjspui/handle/1/9696
Title: Osteoporosis in anorexia nervosa: the influence of peak bone density, bone loss, oral contraceptive use, and exercise.
Authors: Seeman, Ego;Szmukler, G I;Formica, C;Tsalamandris, Con;Mestrovic, R
Affiliation: Department of Endocrinology, Austin Hospital, Melbourne, Australia.
Issue Date: 1-Dec-1992
Citation: Journal of Bone and Mineral Research : the Official Journal of the American Society For Bone and Mineral Research; 7(12): 1467-74
Abstract: Anorexia nervosa occurs early in life and predisposes to osteoporosis. Exercise may be protective. We asked: (1) Does failure to attain peak bone density contribute to the deficit in bone density? (2) Does oral contraceptive use protect against osteoporosis? (3) Is any protective effect of exercise confined to weight-bearing sites? Areal bone density (g/cm2) and body composition were measured by dual x-ray absorptiometry in 65 patients with anorexia nervosa and 52 controls. Comparing the 12 patients with primary amenorrhea and the 37 patients with secondary amenorrhea, bone density (mean +/- SEM) at the lumbar spine was 0.88 +/- 0.04 versus 1.06 +/- 0.03 (P = 0.001), respectively. Bone density at the femoral neck was 0.80 +/- 0.04 versus 0.92 +/- 0.03 (P < 0.05), respectively. These values differed before, but not after, adjusting for the respective duration of illness (73.0 +/- 10.3 versus 34.1 +/- 4.8 months, P < 0.001) and fat-free mass (31.6 +/- 1.3 versus 35.4 +/- 0.5 kg, P < 0.01). Bone density at the lumbar spine in the 16 patients with 31.8 +/- 8.3 months of contraceptive exposure was higher than in the 49 patients with no contraceptive exposure (1.14 +/- 0.05 versus 1.02 +/- 0.02 P < 0.02) but was lower than in controls (1.14 +/- 0.05 versus 1.27 +/- 1.02, P < 0.01). No protective effect of contraceptive exposure was detectable at the femoral neck.(ABSTRACT TRUNCATED AT 250 WORDS)
Internal ID Number: 1481732
URI: http://ahro.austin.org.au/austinjspui/handle/1/9696
DOI: 10.1002/jbmr.5650071215
URL: http://www.ncbi.nlm.nih.gov/pubmed/1481732
Type: Journal Article
Subjects: Amenorrhea
Australia
Biology
Body Weight
Case Control Studies
Comparative Studies
Contraception
Contraceptive Methods--side effects
Deficiency Diseases
Developed Countries
Diseases
Endocrine System
Estrogens
Family Planning
Hormones
Menstruation Disorders
Nutrition Disorders
Oceania
Oral Contraceptives--side effects
Physiology
Research Methodology
Studies
Treatment
Absorptiometry, Photon
Adult
Amenorrhea.etiology.physiopathology
Anorexia Nervosa.complications.physiopathology
Body Composition
Bone Density
Contraceptives, Oral.pharmacology
Exercise
Female
Femur
Humans
Lumbar Vertebrae
Osteoporosis.etiology.physiopathology
Regression Analysis
Appears in Collections:Journal articles

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