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|Title:||fMRI "deactivation" of the posterior cingulate during generalized spike and wave.|
|Authors:||Archer, John S;Abbott, David F;Waites, Anthony B;Jackson, Graeme D|
|Affiliation:||Brain Research Institute, Neurosciences Building, Austin & Repatriation Medical Centre, Banksia Street, Heidelberg West, 3081, Victoria, Australia.|
|Citation:||Neuroimage; 20(4): 1915-22|
|Abstract:||Using spike-triggered fMRI, we sought to document regional changes in blood oxygen level-dependent (BOLD) activity associated with spontaneous generalised spike and slow-wave discharges (S&W). Five adult patients were studied who had idiopathic generalised epilepsy (IGE) and frequent S&W. EEG was recorded inside a 3T MRI, allowing acquisition of single, whole-brain fMRI images following S&W, as well as baseline images. Between 4 and 25 spike and wave complexes were captured in individuals. Four of the five individuals showed significant S&W-related BOLD signal reductions ("deactivation") in the posterior cingulate (P<0.001 uncorrected). Significant changes were absent only in the individual with fewest spikes. Group analysis including all five subjects confirmed fMRI deactivation in the posterior cingulate. Some S&W-related BOLD signal increases were seen in the depths of the precentral sulci in individuals and on group analysis. No significant S&W-related changes in thalamic BOLD activity were observed. The posterior cingulate may have a role in the electroclinical phenomenon of S&W and "absence." Possibilities include a causative role, with reduced activity in the cingulate facilitating the onset of S&W, a secondary role, explaining the cognitive changes observed during prolonged S&W, or an epiphenomenon.|
|Internal ID Number:||14683697|
Image Interpretation, Computer-Assisted
Magnetic Resonance Imaging
|Appears in Collections:||Journal articles|
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