Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/9618
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dc.contributor.authorAllen, A Men
dc.contributor.authorMacGregor, Duncanen
dc.contributor.authorChai, Syn Yen
dc.contributor.authorDonnan, Geoffrey Aen
dc.contributor.authorKaczmarczyk, Sen
dc.contributor.authorRichardson, Ken
dc.contributor.authorKalnins, Renate Men
dc.contributor.authorIreton, Jen
dc.contributor.authorMendelsohn, Frederick AOen
dc.date.accessioned2015-05-15T22:46:55Z
dc.date.available2015-05-15T22:46:55Z
dc.date.issued1992-09-01en
dc.identifier.citationAnnals of Neurology; 32(3): 339-44en
dc.identifier.govdoc1416803en
dc.identifier.otherPUBMEDen
dc.identifier.urihttps://ahro.austin.org.au/austinjspui/handle/1/9618en
dc.description.abstractIn the human brain, receptor binding sites for angiotensin are found in the striatum and in the substantia nigra pars compacta overlying dopamine-containing cell bodies. In contrast, angiotensin-converting enzyme occurs in the substantia nigra pars reticulata and is enriched in the striosomes of the striatum. In this study, using quantitative in vitro autoradiography, we demonstrate decreased angiotensin receptor binding in the substantia nigra and striatum of postmortem brains from patients with Parkinson's disease. In the same brains the density of binding to angiotensin-converting enzyme shows no consistent change. We propose, from these results, that angiotensin receptors in the striatum are located presynaptically on dopaminergic terminals projecting from the substantia nigra. In contrast, the results support previous studies in rats demonstrating that angiotensin-converting enzyme is associated with striatal neurons projecting to the substantia nigra pars reticulata. These findings raise the possibility that newly emerging drugs that interact with the angiotensin system, particularly converting enzyme inhibitors and new nonpeptide angiotensin receptor blockers, may modulate the brain dopamine system.en
dc.language.isoenen
dc.subject.otherAgeden
dc.subject.otherAged, 80 and overen
dc.subject.otherAngiotensin II.analogs & derivatives.metabolismen
dc.subject.otherCorpus Striatum.metabolism.pathologyen
dc.subject.otherDopamine.metabolismen
dc.subject.otherFemaleen
dc.subject.otherHumansen
dc.subject.otherMaleen
dc.subject.otherNeurons.metabolismen
dc.subject.otherParkinson Disease.metabolism.pathologyen
dc.subject.otherPutamen.metabolism.pathologyen
dc.subject.otherReceptors, Angiotensin.metabolismen
dc.subject.otherSubstantia Nigra.metabolism.pathologyen
dc.titleAngiotensin II receptor binding associated with nigrostriatal dopaminergic neurons in human basal ganglia.en
dc.typeJournal Articleen
dc.identifier.journaltitleAnnals of Neurologyen
dc.identifier.affiliationUniversity of Melbourne Department of Medicine, Austin Hospital, Heidelberg, Victoria, Australiaen
dc.identifier.doi10.1002/ana.410320306en
dc.description.pages339-44en
dc.relation.urlhttps://pubmed.ncbi.nlm.nih.gov/1416803en
dc.type.austinJournal Articleen
local.name.researcherDonnan, Geoffrey A
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.cerifentitytypePublications-
item.fulltextNo Fulltext-
item.grantfulltextnone-
item.languageiso639-1en-
item.openairetypeJournal Article-
crisitem.author.deptThe Florey Institute of Neuroscience and Mental Health-
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