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Title: | Subjective quality of life assessment in hemodialysis patients at different levels of hemoglobin following use of recombinant human erythropoietin. | Austin Authors: | McMahon, L P;Dawborn, J K | Affiliation: | Department of Medicine, Austin Hospital, Heidelberg, Victoria, Australia | Issue Date: | 16-May-1992 | Publication information: | American Journal of Nephrology; 12(3): 162-9 | Abstract: | The quality of life of 12 hemodialysis (HD) patients was assessed in a prospective, blinded, cross-over fashion before treatment with recombinant human erythropoietin (r-HuEPO) and at two different levels of hemoglobin (Hb, 9 and 12 g/dl) by means of an interviewer-based questionnaire, the sickness impact profile (SIP). Patients were matched into two groups with no significant difference for age, weight, Hb (6.3 +/- 0.5, mean +/- SEM, group A, vs. 6.4 +/- 0.9 group B), length of hemodialysis or number of years of prior transplantation. SIP was assessed prior to treatment, after reaching the first target Hb (Hb 9 g/dl group A, 12 g/dl group B), after 4 months at that target Hb and after 4 months at the alternative target Hb for each group. For all patients, there was a highly significant improvement in quality of life as assessed by lower SIP scores between the initial and second assessments. This was evident for the physical (8.9 +/- 1.4 vs. 2.8 +/- 1.0; p less than 0.001) and psychosocial (14.9 +/- 3.9 vs. 4.4 +/- 1.1; p less than 0.01) dimensions. Total scores (16.3 +/- 2.4 vs. 5.7 +/- 0.9; p less than 0.001) showed similar changes, reflecting significant improvement in 10 of 12 possible categories between the first two assessments (p less than 0.05 to p less than 0.001). Improved scores were maintained but did not change appreciably after the 2nd assessment. There was no significant difference in any score (category, dimensional or total) obtained after 4 months at Hb 9 g/dl compared to those after the same period at Hb 12 g/dl.(ABSTRACT TRUNCATED AT 250 WORDS) | Gov't Doc #: | 1415377 | URI: | https://ahro.austin.org.au/austinjspui/handle/1/9617 | Journal: | American journal of nephrology | URL: | https://pubmed.ncbi.nlm.nih.gov/1415377 | Type: | Journal Article | Subjects: | Anemia.drug therapy.etiology.psychology Attitude to Health Erythropoietin.therapeutic use Hemoglobins.analysis Humans Kidney Failure, Chronic.complications.therapy Middle Aged Prospective Studies Quality of Life Questionnaires Recombinant Proteins.therapeutic use Renal Dialysis.psychology |
Appears in Collections: | Journal articles |
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